{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:57:36Z","timestamp":1773388656001,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether combination treatment of prostate\u2010specific membrane antigen (PSMA)\u2010based radioguided surgery (RGS) with short\u2010term androgen deprivation therapy (ADT) improves oncological outcomes in men with oligorecurrent prostate cancer (PCa) as compared to treatment with short\u2010term ADT only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TRACE\u2010II study is an investigator\u2010initiated, prospective, randomised controlled clinical trial. Patients (aged &gt;18\u2009years) with hormone\u2010sensitive recurrent PCa after radical prostatectomy or radiotherapy (brachytherapy or external beam radiotherapy), with involvement of \u22642 lymph nodes or local oligorecurrent disease within the pelvis as determined by PSMA positron emission tomography (PET)\/computed tomography (CT) are randomly assigned in a 1:1 ratio between 6\u2010month ADT (Arm A) or 6\u2010month ADT plus RGS (Arm B). The primary objective is to determine clinical progression\u2010free survival (CPFS) at 24\u2009months. After PSMA\u2010RGS, CPFS is defined as the time between the start of treatment and the appearance of a re\u2010recurrence (any N1 or M1) as suggested by PSMA\u2010PET\/CT or symptoms related to progressive PCa, or death from any cause. The secondary objectives include metastasis\u2010free survival at 2, 5 and 10\u2009years, biochemical progression\u2010free survival at 2\u2009years, and patient\u2010reported quality of life at 2, 5 and 10\u2009years. A total of 60 patients, 30 per arm, will be included. The trial is powered (80%) to detect at least a 30% absolute difference in CPFS between the two study arms in the period 2\u2009years after randomisation. We expect to enrol the required participants in 3\u2009years. The study has an expected duration of 5\u2009years in total.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining RGS with short\u2010term ADT might be oncologically beneficial for patients with oligorecurrent PCa. In this first randomised controlled trial, we are investigating the potential oncological benefits of this combined treatment, while also focusing on maintaining quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16297","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T22:18:57Z","timestamp":1707776337000},"page":"81-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>\n                      <sup>99m<\/sup>\n                      TcPSMA\n                    <\/scp>\n                    \u2010radioguided surgery in oligorecurrent prostate cancer: the randomised\n                    <scp>TRACE\u2010II<\/scp>\n                    trial"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7392-1626","authenticated-orcid":false,"given":"Lotte G.","family":"Zuur","sequence":"first","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-7897","authenticated-orcid":false,"given":"Hilda A.","family":"de Barros","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias N.","family":"van Oosterom","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Department of Radiology, Interventional Molecular Imaging Laboratory Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Claire","family":"Berrens","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"},{"name":"Department of Radiology, Interventional Molecular Imaging Laboratory Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten L.","family":"Donswijk","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen J.M.A.","family":"Hendrikx","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Department of Clinical Pharmacy &amp; Pharmacology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise M.","family":"Bekers","sequence":"additional","affiliation":[{"name":"Department of Pathology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 N.","family":"Vis","sequence":"additional","affiliation":[{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"},{"name":"Department of Urology Amsterdam University Medical Centres  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"Wit","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fijs B.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Department of Radiology, Interventional Molecular Imaging Laboratory Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-1120","authenticated-orcid":false,"given":"Henk G.","family":"van der Poel","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"},{"name":"Department of Urology Amsterdam University Medical Centres  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim J.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"},{"name":"Netherlands Prostate Cancer Network  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70163-4"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(199604)28:4<266::AID-PROS7>3.0.CO;2-B"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13540"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.03.013"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13397"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.196683"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.03.002"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.178939"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-020-00095-9"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.09.014"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.05.031"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00655-9"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.1.8"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0119-7"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.06.043"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.4487"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.140426"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.08.003"},{"key":"e_1_2_14_20_1","unstructured":"SchaefferEMC AnY BarocasDMPHet\u00a0al.NCCN guidelines version 1.2023 prostate cancer.2022"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.02.011"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.08.082"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.02.015"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.08.056"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.041"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.045"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.034"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0147"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00644"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.4853"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.0161"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:06:56Z","timestamp":1761736016000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/bju.16297"],"URL":"https:\/\/doi.org\/10.1111\/bju.16297","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"assertion":[{"value":"2024-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}