{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:26:57Z","timestamp":1768004817703,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011338","name":"AstraZeneca Schweiz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report on the surgical safety and quality of pelvic lymph node dissection (PLND) in patients treated with radical cystectomy (RC) and PLND for muscle\u2010invasive bladder cancer (MIBC) after neoadjuvant chemo\u2010immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The Swiss Group for Clinical Cancer Research (SAKK) 06\/17 was an open\u2010label single\u2010arm phase II trial including 61 cisplatin\u2010fit patients with clinical stage (c)T2\u2013T4a cN0\u20131 operable urothelial MIBC or upper urinary tract cancer. Patients received neoadjuvant cisplatin\/gemcitabine and durvalumab followed by surgery. Prospective quality assessment of surgeries was performed via central review of intraoperative photographs. Postoperative complications were assessed using the Clavien\u2013Dindo Classification. Data were analysed descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 50 patients received RC and PLND. All patients received neoadjuvant chemo\u2010immunotherapy. The median (interquartile range) number of lymph nodes removed was 29\u2009(23\u201338). No intraoperative complications were registered. Grade \u2265III postoperative complications were reported in 12 patients (24%). Complete nodal dissection (100%) was performed at the level of the obturator fossa (bilaterally) and of the left external iliac region; in 49 patients (98%) at the internal iliac region and at the right external iliac region; in 39 (78%) and 38 (76%) patients at the right and left presacral level, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports the surgical safety of RC and PLND following neoadjuvant chemo\u2010immunotherapy in patients with MIBC. The extent and completeness of protocol\u2010defined PLND varies between patients, highlighting the need to communicate and monitor the surgical template.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16318","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T06:34:33Z","timestamp":1709879673000},"page":"388-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and quality of cystectomy and pelvic lymph node dissection after neoadjuvant durvalumab and cisplatin\/gemcitabine"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-1933","authenticated-orcid":false,"given":"Luca","family":"Afferi","sequence":"first","affiliation":[{"name":"Department of Urology Luzerner Kantonsspital  Lucerne 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