{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:58:47Z","timestamp":1767999527638,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the impact of the learning curve (LC) on perioperative and long\u2010term functional outcomes of a consecutive single\u2010centre series of robot\u2010assisted radical cystectomy with Padua intracorporeal orthotopic neobladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients treated between 2013 and 2022 were included, with \u22651\u2009year of follow\u2010up. The entire cohort was divided in tertiles. Categorical and continuous variables were compared. Joinpoint regression analysis was used to identify significant changes over the decade in linear slope of the 1\u2010year day\u2010 and night\u2010time continence. Uni\u2010 and multivariable Cox regression analyses identified predictors of day\u2010 and night\u2010time continence recovery. Day\u2010time continence was defined as \u2018totally dry\u2019 (no pads), night\u2010time continence as pad wetness \u226450\u2009mL (one safety pad).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 200 patients were included. The mean hospital stay (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and 30\u2010day complications (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) significantly reduced over time; the LC significantly impacted on Trifecta achievement (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 1\u2010year day\u2010 and night\u2010time continence probabilities displayed a significant improving trend (day\u2010time continence annual average percentage change [AAPC] 11.45%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; night\u2010time continence AAPC 10.05%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009). The LC was an independent predictor of day\u2010 (hazard ratio [HR] 1.008;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and night\u2010time continence (HR 1.004;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients at the beginning of the LC had significantly longer hospitalisations, more postoperative complications, and lower Trifecta rates. At the 10\u2010year analyses, we observed a significant improving trend for both the 1\u2010year day\u2010 and night\u2010time continence probabilities, highlighting the crucial role of the LC. However, we are unable to assess the case volume needed to achieve a plateau in terms of day\u2010 and night\u2010time continence rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16328","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T00:29:47Z","timestamp":1709944187000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Learning curve for intracorporeal robotic Padua ileal\u00a0bladder: 10\u2010year functional assessment from a high\u2010volume single\u2010centre series"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4480-9090","authenticated-orcid":false,"given":"Gabriele","family":"Tuderti","sequence":"first","affiliation":[{"name":"Department of Urology IRCCS \u2018Regina Elena\u2019 National Cancer Institute  Rome 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