{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:49Z","timestamp":1787013949205,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170792"],"award-info":[{"award-number":["82170792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7222235"],"award-info":[{"award-number":["7222235"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3606003"],"award-info":[{"award-number":["2023YFC3606003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of a wearable, smartphone\u2010controlled, rechargeable transcutaneous tibial nerve stimulation (TTNS) device in patients with overactive bladder (OAB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This multicentre, prospective, single\u2010blind, randomised clinical trial included eligible patients with OAB symptoms who were randomly assigned to the stimulation group or sham group. The primary efficacy outcome was change from baseline in voiding frequency\/24\u2009h after 4\u2009weeks of treatment. The secondary efficacy outcomes included changes in bladder diary outcomes (urgency score\/void, nocturia episodes\/day, micturition volume\/void, and incontinence episodes\/day), questionnaires on Overactive Bladder Symptom Score (OABSS), Patient Perception of Bladder Condition (PPBC), and American Urological Association Symptom Index Quality of Life Score (AUA\u2010SI\u2010QoL) at baseline and after 4\u2009weeks of treatment. Device\u2010related adverse events (AEs) were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the full analysis set (FAS), the mean (\n                      <jats:sc>sd)<\/jats:sc>\n                      change of voiding frequency\/24\u2009h in the stimulation group and sham group at 4\u2009weeks were \u22123.5\u2009(2.9) and \u22120.6\u2009(2.4), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Similar results were obtained in the per\u2010protocol set (PPS): \u22123.5\u2009(2.9) vs \u22120.4\u2009(2.3) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). In the FAS and PPS, micturition volume\/void significantly improved at 4\u2009weeks (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). PPBC improvement almost reached significance in the FAS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05), while it was significant in the PPS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02). In the FAS and PPS, AUA\u2010SI\u2010QoL significantly improved at 4\u2009weeks in the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas there were no significant differences in urgency score\/void, nocturia episodes\/day or OABSS between the groups. Also, no device\u2010related serious AEs were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The non\u2010invasive neuromodulation technique using the novel ambulatory TTNS device is effective and safe for treating OAB. Its convenience and easy maintenance make it a new potential home\u2010based treatment modality. Future studies are warranted to confirm its longer\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16330","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T01:38:29Z","timestamp":1710207509000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy and safety of tibial nerve stimulation using a wearable device for overactive bladder"],"prefix":"10.1111","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7092-6576","authenticated-orcid":false,"given":"Limin","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Centre, China Rehabilitation Science Institute Rehabilitation School of Capital Medical University  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-8700","authenticated-orcid":false,"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Centre, China Rehabilitation Science Institute Rehabilitation School of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-6544","authenticated-orcid":false,"given":"Tie","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Urology Second Affifiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Second Affifiliated Hospital of Xi\u2019an Jiaotong University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Zhejiang Provincial People\u2019s Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banggao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Zhejiang Provincial People\u2019s Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Urology Second Affifiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Urology Second Affifiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Centre, China Rehabilitation Science Institute Rehabilitation School of Capital Medical University  Beijing China"},{"name":"University of Health and Rehabilitation Sciences  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, China Rehabilitation Research Centre, China Rehabilitation Science Institute Rehabilitation School of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.11.024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.01.045"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.087"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13847"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.175"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23843"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24876"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03450-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.872200"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.09.020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24595"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.4.5.693"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001105"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001733"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.10.017"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02666-w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-018-0553-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2018.09.12"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06827-3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03235-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.036"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1938232.116"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14342"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1115433"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:24:46Z","timestamp":1761744286000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/bju.16330"],"URL":"https:\/\/doi.org\/10.1111\/bju.16330","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"2024-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}