{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:02:37Z","timestamp":1761746557218,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the interaction of patient age and Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score in determining the grade of prostate cancer (PCa) identified on magnetic resonance imaging (MRI)\u2010targeted biopsy in older men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>From a prospectively accrued Institutional Review Board\u2010approved comparative study of MRI\u2010targeted and systematic biopsy between June 2012 and December 2022, men with at least one PI\u2010RADS \u22653 lesion on pre\u2010biopsy MRI and no prior history of PCa were selected. Ordinal and binomial logistic regression analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2677 men met study criteria. The highest PI\u2010RADS score was 3 in 1220 men (46%), 4 in 950 men (36%), and 5 in 507 men (19%). The median (interquartile range [IQR]) patient age was 66.7\u2009(60.8\u201371.8)\u2009years, median (IQR) prostate\u2010specific antigen (PSA) level was 6.1\u2009(4.6\u20139.0)\u2009ng\/mL, median (IQR) prostate volume was 48\u2009(34\u201368)\u2009mL, and median (IQR) PSA density was 0.13\u2009(0.08\u20130.20)\u2009ng\/mL\/mL. Clinically significant (cs)PCa and high\u2010risk PCa were identified on targeted biopsy in 1264 (47%) and 321 (12%) men, respectively. Prevalence of csPCa and high\u2010risk PCa were significantly higher in the older age groups. On multivariable analyses, patient age was significantly associated with csPCa but not high\u2010risk PCa; PI\u2010RADS score and the interaction of age and PI\u2010RADS score were significantly associated with high\u2010risk PCa but not csPCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort, the substantial rate of high\u2010risk PCa on MRI\u2013ultrasound fusion targeted biopsies in older men, and its significant association with MRI findings, supports the value of pre\u2010biopsy MRI to localise disease that could cause cancer mortality even in older men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16341","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T03:50:13Z","timestamp":1711511413000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction of patient age and high\u2010grade prostate cancer on targeted biopsies of MRI suspicious lesions"],"prefix":"10.1111","volume":"134","author":[{"given":"Jamie S.","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Lepor","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-0947","authenticated-orcid":false,"given":"James S.","family":"Wysock","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir S.","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Urology NYU Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.05.078"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30569-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.11.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.06.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.01.071"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.12.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.01.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.09.139"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.130"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.2075"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122233"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.048"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3710"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003491"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-019-0212-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2023.01.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.12.005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34355"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14935"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.11.018"},{"key":"e_1_2_7_27_1","unstructured":"Website.Social Society Actuarial Life Table.https:\/\/www.ssa.gov\/oact\/STATS\/table4c6.html. 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