{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:32:34Z","timestamp":1791203554686,"version":"4.2.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report non\u2010infectious adverse events associated with transperineal prostate biopsy (TPBx) performed under local anaesthesia (LA) in an outpatient setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This study reports secondary outcomes from the Norwegian arm of the prospective NORAPP study (ClinicalTrials.gov identifier NCT04146142) and included all patients referred for prostate biopsy from November 2019 to February 2021. Transperineal magnetic resonance imaging\u2010transrectal ultrasonography fusion TPBx were taken using 40\u2009mL 1% lidocaine with 4\u2009mL of 8.4% sodium bicarbonate placed in the perineal skin, under the prostatic apex, in the m. levator ani bilaterally, and along the path of the needle. Follow\u2010up using patient\u2010reported questionnaires was done immediately after TPBx, and after 2\u2009weeks and 2\u2009months. Pain was reported using a visual analogue scale (VAS) during placement of the LA, and during and after TPBx. Haematuria and acute urinary retention (AUR) rates were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 402 patients, and the response rate was 99.8% (401\/402). The median (interquartile range [IQR]) age was 69\u2009(63\u201374)\u2009years, the prostate volume was 40\u2009(27\u201358)\u2009mL, the prostate\u2010specific antigen level was 7.0\u2009(4.5\u201311)\u2009ng\/mL, and the number of biopsy cores taken was 8\u2009(6\u201310). The median (IQR) VAS pain score was 1\u2009(1\u20132) during placement of LA, 1\u2009(0\u20132) during TPBx, and 0\u2009(0\u20130) after TPBx. Haematuria and AUR rates were 64% (95% confidence interval [CI] 60\u201369%) and 0.5% (95% CI 0.1\u20131.8%), respectively. No patients were hospitalised or required after the TPBx surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transperineal prostate biopsies can be performed under LA with limited discomfort to the patient and few post\u2010TPBx adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16383","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T19:24:00Z","timestamp":1714332240000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Non\u2010infectious adverse events of transperineal prostate biopsies performed under local anaesthesia"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9497-6893","authenticated-orcid":false,"given":"Maciej","family":"Jacewicz","sequence":"first","affiliation":[{"name":"Department of Urology Oslo University Hospital  Oslo Norway"},{"name":"University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Rud","sequence":"additional","affiliation":[{"name":"Department of Radiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lauritzen","sequence":"additional","affiliation":[{"name":"Department of Radiology Oslo University Hospital  Oslo Norway"},{"name":"Department of Life Sciences and Health Oslo Metropolitan University  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Baco","sequence":"additional","affiliation":[{"name":"Department of Urology Oslo University Hospital  Oslo Norway"},{"name":"University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Presented at the EAU Annual Congress Milan 2023","author":"Mottet N","year":"2023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15039"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15906"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bco2.112"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15590"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00373-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002251"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-022-00641-3"},{"key":"e_1_2_7_10_1","first-page":"19","article-title":"Transrectal ultrasound\u2010guided versus transperineal mapping prostate biopsy: complication comparison","volume":"20","author":"Skouteris VM","year":"2018","journal-title":"Rev Urol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.01.103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2014.0607"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bco2.178"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.06.033"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000156"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15244"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-018-0730-x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen103"},{"key":"e_1_2_7_19_1","unstructured":"Sergeant.Epitools epidemiological calculators.2018[cited 2021]; 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