{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:49:11Z","timestamp":1791557351919,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the feasibility of fluorescence molecular imaging (FMI), using cetuximab\u2010800CW, as an intraoperative tool to determine surgical margins in penile squamous cell carcinoma (PSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A total of 11 patients with PSCC received 75\u2009mg cetuximab followed by 15\u2009mg cetuximab\u2010800CW 2\u2009days before surgery. FMI of the whole excision specimen and tissue slices was performed. Fluorescence visualisation was correlated to histopathology. Based on tumour and healthy tissue regions of interest, mean fluorescence intensity was calculated for each individual patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant differences between tumour and healthy mean fluorescence intensity were found with tumour\u2010to\u2010background ratios of a median (IQR) of 1.51\u2009(0.99) and a mean (SD) of 1.51\u2009(0.32) in the excision specimen and tissue slices, respectively. One patient showed a high relative fluorescence intensity with a signal\u2010to\u2010background ratio of 1.79, corresponding to a tumour\u2010positive margin on fresh frozen sectioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this Phase I study we showed that cetuximab\u2010800CW seems suitable to discriminate PSCC from background tissue. The tracer was well tolerated, and no false positive spots were seen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16384","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T02:25:15Z","timestamp":1714011915000},"page":"268-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fluorescence\u2010guided surgery using cetuximab\u2010800CW in patients with penile carcinoma"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-451X","authenticated-orcid":false,"given":"Thomas S.","family":"Nijboer","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa A. 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