{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:34Z","timestamp":1792512094501,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess histopathological outcomes, as well as feasibility and safety of targeted microwave ablation (TMA) via the Trinity\u00ae system (KOELIS, La Tronche, France).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Prospective, single\u2010institution, interventional Phase IIa study with an \u2018ablate\u2010and\u2010resect\u2019 design. In all, 11 patients diagnosed with localised prostate cancer (PCa) underwent TMA via the Trinity system under conscious sedation in an outpatient setting using a single transrectal TATO\u00ae 18\u2010G antenna with different treatment regimens. Magnetic resonance imaging (MRI) and robot\u2010assisted radical prostatectomy (RARP) were conducted at 7\u2009days and 1\u2009month after TMA, respectively. Nine patients received RARP, and two patients chose to withdraw their consent following TMA. These men chose an active surveillance protocol upon confirmation of a low\u2010risk prostate cancer diagnosis. Functional outcomes and adverse events were evaluated at baseline and follow\u2010up visits using validated questionnaires. Prostate volumetry and confirmation of necrosis were carried out through MRI and whole\u2010mount histopathological examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The TMA was successfully executed, and all patients were discharged on the same day. No severe adverse events (Common Terminology Criteria for Adverse Events Grade \u22653) were reported at the 7\u2010day and 1\u2010month follow\u2010up visits. Additionally, no declines were observed in urinary, sexual and ejaculation functional outcomes. T1\u2010weighted MRI revealed clear and well\u2010defined ablation zones. The RARP was executed without difficulty, particularly during the dissection of the posterior plane. As a result, no intraoperative complications were encountered. Histopathological assessment on surgical specimens confirmed the absence of viable cells, indicating complete necrosis of the ablative zone if a power intensity &gt;10\u2009W was used during TMA. Ablation zone volumetry revealed no notable distinctions between the three\u2010dimensional segmentation of the virtual ablation zone at TMA (median volume: 2\u2009mL) and MRI (median volume: 1.923\u2009mL). Conversely, a significant reduction was noted in the surgical specimen (median volume: 0.221\u2009mL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeted microwave ablation via the Trinity system for localised PCa treatment proves to be a secure and feasible procedure, with complete necrosis evidence within the ablation zone on surgical specimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16385","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T05:07:08Z","timestamp":1715663228000},"page":"258-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeted microwave ablation for prostate cancer (FOSTINE1b): a prospective \u2018ablate\u2010and\u2010resect\u2019 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