{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:47:11Z","timestamp":1788173231320,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017037","name":"Cepheid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate and compare the performance of urinary cytology and the Xpert BC Monitor test in the detection of bladder cancer in various clinically significant patient cohorts, including patients with carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      (CIS), in a prospective multicentre setting, aiming to identify potential applications in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 756 patients scheduled for transurethral resection of bladder tumour (TURBT) were prospectively screened between July 2018 and December 2020 at six German University Centres. Central urinary cytology and Xpert BC Monitor tests were performed prior to TURBT. The diagnostic performance of urinary cytology and the Xpert BC Monitor was evaluated according to sensitivity (SN), specificity (SC), negative predictive value (NPV) and positive predictive value (PPV). Statistical comparison of urinary cytology and the Xpert BC Monitor was conducted using the McNemar test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 756 screened patients, 733 (568 male [78%]; median [interquartile range] age 72\u2009[62\u201379] years) were included. Bladder cancer was present in 482 patients (65.8%) with 258 (53.5%) high\u2010grade tumours. Overall SN, SC, NPV and PPV were 39%, 93%, 44% and 92% for urinary cytology, and 75%, 69%, 59% and 82% for the Xpert BC Monitor. In patients with CIS (concomitant or solitary), SN, SC, NPV and PPV were 59%, 93%, 87% and 50% for urinary cytology, and 90%, 69%, 95% and 50% for the Xpert BC Monitor. The Xpert BC Monitor missed four tumours (NPV\u2009=\u200998%) in patients with solitary CIS, while potentially avoiding 63.3% of TURBTs in inconclusive or negative cystoscopy and a negative Xpert result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Positive urinary cytology may indicate bladder cancer and should be taken seriously. The Xpert BC Monitor may represent a useful diagnostic tool for correctly identifying patients with solitary CIS and unsuspicious or inconclusive cystoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16389","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T07:49:16Z","timestamp":1715154556000},"page":"755-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improving detection of carcinoma\n                    <i>in situ<\/i>\n                    in bladder cancer: urinary cytology vs the Xpert\u00ae\n                    <scp>BC<\/scp>\n                    Monitor"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3132-0130","authenticated-orcid":false,"given":"Maximilian","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Urology, Caritas St. Josef Medical Center University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian C.","family":"Kriegmair","sequence":"additional","affiliation":[{"name":"Department of Urology and Urosurgery, Medical Faculty Mannheim, University Hospital Mannheim University of Heidelberg  Mannheim Germany"},{"name":"Urological Hospital Munich\u2010Planegg  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-4150","authenticated-orcid":false,"given":"Johannes","family":"Breyer","sequence":"additional","affiliation":[{"name":"Department of Urology, Caritas St. Josef Medical Center University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijel","family":"Sikic","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology Friedrich\u2010Alexander\u2010University Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Wezel","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology University of Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Roghmann","sequence":"additional","affiliation":[{"name":"Department of Urology, Marien Hospital Ruhr\u2010University Bochum  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirco","family":"Brehmer","sequence":"additional","affiliation":[{"name":"Department of Urology, Marien Hospital Ruhr\u2010University Bochum  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph M.","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Stratifyer Molecular Pathology GmbH  Cologne Germany"},{"name":"Institute of Pathology St. Elisabeth Hospital K\u00f6ln\u2010Hohenlind  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Jarczyk","sequence":"additional","affiliation":[{"name":"Department of Urology and Urosurgery, Medical Faculty Mannheim, University Hospital Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Erben","sequence":"additional","affiliation":[{"name":"Department of Urology and Urosurgery, Medical Faculty Mannheim, University Hospital Mannheim University of Heidelberg  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Bahlinger","sequence":"additional","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander\u2010University Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Fechner","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Chen","sequence":"additional","affiliation":[{"name":"Biostatistics Cepheid Inc.  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