{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:00Z","timestamp":1792381200997,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effectiveness of low intra\u2010abdominal pressure (IAP) facilitated by deep neuromuscular block (NMB) to standard practice in improving the quality of recovery, preserving immune function, and enhancing parietal perfusion during robot\u2010assisted radical prostatectomy (RARP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      In this blinded, randomised controlled trial, 96 patients were randomised to the experimental group with low IAP (8\u2009mmHg) facilitated by deep NMB (post\u2010tetanic count 1\u20132) or the control group with standard IAP (14\u2009mmHg) and moderate NMB (train\u2010of\u2010four 1\u20132). Recovery was measured using the 40\u2010item Quality of Recovery questionnaire and 36\u2010item Short\u2010Form Health survey. Immune function was evaluated by plasma damage\u2010associated molecular patterns, cytokines, and\n                      <jats:italic>ex vivo<\/jats:italic>\n                      lipopolysaccharide\u2010stimulated cytokine production. Parietal peritoneum perfusion was measured by analysing the recordings of indocyanine\u2010green injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Quality of recovery was not superior in the experimental group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946) compared to the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950). All clinical outcomes, including pain scores, postoperative nausea and vomiting, and hospital stay were similar. There were no significant differences in postoperative plasma concentrations of damage\u2010associated molecular patterns, cytokines, and\n                      <jats:italic>ex vivo<\/jats:italic>\n                      cytokine production capacity. The use of low IAP resulted in better parietal peritoneum perfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite better perfusion of the parietal peritoneum, low IAP facilitated by deep NMB did not improve the quality of recovery or preserve immune function compared to standard practice in patients undergoing RARP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16397","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:04:05Z","timestamp":1716523445000},"page":"416-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recovery and immune function after low pressure pneumoperitoneum during robot\u2010assisted radical prostatectomy: a randomised controlled trial"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-3921","authenticated-orcid":false,"given":"Gabby T. J. A.","family":"Reijnders\u2010Boerboom","sequence":"first","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Canisius Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5169-1970","authenticated-orcid":false,"given":"Lotte M. C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie S.","family":"Helder","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo F.","family":"Panhuizen","sequence":"additional","affiliation":[{"name":"Canisius Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik P. J.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim I.","family":"Albers","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Loonen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert Jan","family":"Scheffer","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"Keijzer","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center  Nijmegen The 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