{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:01Z","timestamp":1792381201670,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5047\/A21332"],"award-info":[{"award-number":["C5047\/A21332"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5047\/A13232"],"award-info":[{"award-number":["C5047\/A13232"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C5047\/A17528"],"award-info":[{"award-number":["C5047\/A17528"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014461","name":"NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust\/Institute of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS\u2010BRC\u20101215\u201020007"],"award-info":[{"award-number":["IS\u2010BRC\u20101215\u201020007"]}],"id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,9]]},"abstract":"\n Objectives<\/jats:title>\n \n To report the long\u2010term outcomes from a longitudinal psychosocial study that forms part of the \u2018Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls\u2019 (IMPACT) study. The IMPACT study is a multi\u2010national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (\n BRCA1<\/jats:italic>\n ) or the BReast CAncer gene 2 (\n BRCA2<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n Participants enrolled in the\n IMPACT<\/jats:styled-content>\n study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5\u2009years. The questionnaire included questions on sociodemographics and the following measures: Hospital Anxiety and Depression Scale, Impact of Event Scale, 36\u2010item Short\u2010Form Health Survey, Memorial Anxiety Scale for\n PrCa<\/jats:styled-content>\n , Cancer Worry Scale, risk perception and knowledge.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 760 participants completed questionnaires: 207 participants with\n GPV<\/jats:styled-content>\n in\n \n BRCA1<\/jats:italic>\n <\/jats:styled-content>\n , 265 with\n GPV<\/jats:styled-content>\n in\n \n BRCA2<\/jats:italic>\n <\/jats:styled-content>\n and 288 controls (non\u2010carriers from families with a known\n GPV<\/jats:styled-content>\n ). We found no evidence of clinically concerning levels of general or cancer\u2010specific distress or poor health\u2010related quality of life in the cohort as a whole. Individuals in the control group had significantly less worry about\n PrCa<\/jats:styled-content>\n compared with the carriers; however, all mean scores were low and within reported general population norms, where available.\n \n BRCA2<\/jats:italic>\n <\/jats:styled-content>\n carriers with previously high prostate\u2010specific antigen\n (PSA)<\/jats:styled-content>\n levels experience a small but significant increase in\n PrCa<\/jats:styled-content>\n anxiety (\n P<\/jats:italic>\n \u2009=\u20090.01) and\n PSA<\/jats:styled-content>\n \u2010specific anxiety (\n P<\/jats:italic>\n \u2009<\u20090.001). Cancer risk perceptions reflected information provided during genetic counselling and participants had good levels of knowledge, although this declined over time.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the first study to report the longitudinal psychosocial impact of a targeted\n PrCa<\/jats:styled-content>\n screening programme for\n \n BRCA1<\/jats:italic>\n <\/jats:styled-content>\n and\n \n BRCA2<\/jats:italic>\n <\/jats:styled-content>\n carriers. The results reassure that an annual\n PSA<\/jats:styled-content>\n \u2010based screening programme does not have an adverse impact on psychosocial health or health\u2010related quality of life in these higher\u2010risk individuals. These results are important as more\n PrCa<\/jats:styled-content>\n screening is targeted to higher\u2010risk groups.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.16432","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T22:26:02Z","timestamp":1717626362000},"page":"484-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The psychosocial impact of prostate cancer screening for\n BRCA1<\/i>\n and\n BRCA2<\/i>\n carriers"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-5660","authenticated-orcid":false,"given":"Elizabeth K.","family":"Bancroft","sequence":"first","affiliation":[{"name":"Oncogenetics Team Royal Marsden NHS Foundation Trust London UK"},{"name":"Oncogenetics Team Institute of Cancer Research London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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