{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:44:26Z","timestamp":1778697866009,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare 1\u2010year functional and 5\u2010year oncological outcomes of men undergoing robot\u2010assisted laparoscopic prostatectomy (RALP) with neurovascular structure\u2010adjacent frozen\u2010section examination (NeuroSAFE) with those in men undergoing RALP without NeuroSAFE (standard of care [SOC]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Men undergoing RALP in our centre between 1 January 2009 and 30 June 2018 were enrolled from a prospectively maintained database. Patients were excluded if they had undergone preoperative therapy or postoperative adjuvant therapy or were enrolled in clinical trials. Patients were grouped based on use of NeuroSAFE. Follow\u2010up was censored at 5\u2009years. The primary outcome was difference in time to biochemical recurrence (BCR) on multivariable analysis, defined as prostate\u2010specific antigen (PSA) &gt;0.2\u2009ng\/L on two consecutive measurements. Secondary outcomes were difference in 1\u2010year erectile dysfunction and incontinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the enrolment period, 1199 consecutive men underwent RALP, of whom 1140 were eligible, including 317 with NeuroSAFE and 823 with SOC. The median PSA follow\u2010up was 60\u2009months in both groups. Rates of 5\u2010year BCR were similar on Kaplan\u2013Meier survival curve analysis (11% vs 11%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.9), as was time to BCR on multivariable Cox proportional hazards modelling (hazard ratio 1.2;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.6). Compared with the SOC group at 1 year, the NeuroSAFE group had similar unadjusted rates of incontinence (5.1% vs 7.7%) and lower unadjusted impotence (57% vs 80%). On multivariable analysis, NeuroSAFE patients had equivalent risk of incontinence (odds ratio [OR] 0.59, 95% CI 0.17\u20131.6;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.4) but significantly reduced risk of erectile dysfunction (OR 0.37, 95% CI 0.22\u20130.60;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>For men undergoing RALP, compared with SOC, NeuroSAFE patients had equivalent time to BCR and risk of 1\u2010year incontinence, and significantly lower risk of 1\u2010year erectile dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16437","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:48:16Z","timestamp":1720061296000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of frozen section on long\u2010term outcomes in robot\u2010assisted laparoscopic prostatectomy"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-2537","authenticated-orcid":false,"given":"Ned","family":"Kinnear","sequence":"first","affiliation":[{"name":"Lister Hospital  Stevenage UK"},{"name":"Flinders Medical Centre  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Cotter","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Lister Hospital  Stevenage 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