{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:14:06Z","timestamp":1790028846777,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the risk of venous thromboembolic events (VTEs) and bleeding with or without thromboprophylaxis during neoadjuvant chemotherapy in bladder cancer patients scheduled for radical cystectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study in 4886 patients with non\u2010metastatic bladder cancer undergoing cystectomy across 28 centres in 13 countries between 1990 and 2021. Inverse probability weighting analyses were performed to estimate the effect of thromboprophylaxis on VTE and bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 147 patients (3%) VTEs were recorded within the first year. These occurred a median (interquartile range [IQR]) of 127 (82\u2013198) days after bladder cancer diagnosis. Bleeding events occurred in 131 patients (3%) within the first year. These occurred a median (IQR) of 101 (83\u2013171) days after cancer diagnosis. In inverse probability weighting analyses, compared to patients without thromboprophylaxis during chemotherapy, patients with thromboprophylaxis had not only a lower risk of VTE (hazard ratio [HR] 0.32, 95% confidence interval [CI] 0.12\u20130.81;\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.016) but also a lower bleeding risk (HR 0.03, 95% CI 0.09\u20130.12;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). The retrospective nature of the study was its main limitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective analysis, the benefit of thromboprophylaxis during neoadjuvant chemotherapy before cystectomy is in line with data from randomised trials in other malignancies. Our data suggest thromboprophylaxis is protective against VTEs and should be the standard of care during neoadjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16444","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T02:54:30Z","timestamp":1720061670000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thromboprophylaxis during neoadjuvant chemotherapy for bladder cancer reduces thromboembolism and bleeding"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-5497","authenticated-orcid":false,"given":"Luca","family":"Antonelli","sequence":"first","affiliation":[{"name":"Department of Urology, Luzerner Kantonsspital University of Lucerne  Lucerne Switzerland"},{"name":"Department of Urology Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro David","family":"Wendel\u2010Garcia","sequence":"additional","affiliation":[{"name":"Department of Biostatistics at the Epidemiology, Biostatistics and Prevention Institute University of Zurich  Zurich Switzerland"},{"name":"Institute of Intensive Care Medicine University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Deforth","sequence":"additional","affiliation":[{"name":"Department of Biostatistics at the Epidemiology, Biostatistics and Prevention Institute University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-1933","authenticated-orcid":false,"given":"Luca","family":"Afferi","sequence":"additional","affiliation":[{"name":"Department of Urology, Luzerner Kantonsspital University of Lucerne  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Department of Urology Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-1864","authenticated-orcid":false,"given":"Francesco","family":"Esperto","sequence":"additional","affiliation":[{"name":"Department of Urology Campus Bio\u2010Medico University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Borghesi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico S. Martino  Genoa Italy"},{"name":"Department of Surgical and Diagnostic Integrated Sciences University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-8803","authenticated-orcid":false,"given":"Alessandro","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Urology Azienda Ospedaliera Universitaria Integrata Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-0169","authenticated-orcid":false,"given":"Karl","family":"Tully","sequence":"additional","affiliation":[{"name":"Departement of Urology and Neurourology, Marien Hospital Herne Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-1559","authenticated-orcid":false,"given":"Paolo","family":"Umari","sequence":"additional","affiliation":[{"name":"St. George's University Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5529-3064","authenticated-orcid":false,"given":"Simone","family":"Albisinni","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Surgical Sciences, Tor Vergata University Hospital University of Rome Tor Vergata  Rome Italy"},{"name":"Service d'Urologie, H\u00f4pital Universitaire de Bruxelles Universit\u00e9 Libre de Bruxelles  Bruxells Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[{"name":"Unit of Oncologic Minimally\u2010Invasive Urology and Andrology \u2010 Careggi Hospital, Department of Clinical and Experimental Medicine University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-9048","authenticated-orcid":false,"given":"Renate","family":"Pichler","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-5553","authenticated-orcid":false,"given":"Francesco","family":"Claps","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Health Sciences, Urological Clinic University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-2342","authenticated-orcid":false,"given":"Jeremy Yuen\u2010Chun","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Surgery, S.H. 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