{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:52:56Z","timestamp":1778629976702,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the outcomes and treatment burden of primary retroperitoneal lymph node dissection (pRPLND) alone versus pRPLND\u2009+\u2009adjuvant chemotherapy (AC) in patients with pathological stage II (PSII) non\u2010seminomatous germ cell tumours (NSGCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Retrospective review of the Princess Margaret Cancer Center eTestes cancer database identified patients with PSII NSGCT after pRPLND between 1995 and 2020. The primary outcome was relapse\u2010free survival (RFS). Secondary outcomes included disease\u2010specific survival (DSS), burden of relapse treatment, and factors associated with relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 109 PSII patients were included in the study. There were 96 patients treated with pRPLND alone and 13 treated with pRPLND\u2009+\u2009AC. The median follow\u2010up was 61\u2009months. The 5\u2010year RFS was 72% for the pRPLND\u2010only group vs 92% for the pRPLND\u2009+\u2009AC group (hazard ratio [HR] 4.372, 95% confidence interval [CI] 0.59\u201332.36;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.11). Within the pRPLND\u2010only group the 5\u2010year RFS differed by pN stage (pN1\u2009=\u200994% vs pN2\/N3\u2009=\u200967%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Despite a higher relapse rate within the pRPLND\u2010only group, the DSS was similar at 5\u2009years (98% pRPLND only vs 100% pRPLND\u2009+\u2009AC,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.48). Only 24 (25%) of the patients in the pRPLND\u2010only group required any subsequent chemotherapy. Despite achieving similar survival, the cumulative post\u2010RPLND treatment burden was less for the pRPLND\u2010only group than the pRPLND+AC group overall (average 1.23 vs 2.46\u2009cycles of chemotherapy per patient in group).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of patients with PSII NSGCT treated with pRPLND alone do not experience a recurrence or require chemotherapy. Despite a lower relapse risk when AC is given, no difference in survival was seen but higher chemotherapy burden was entertained. AC may constitute overtreatment for most patients with PSII NSGCT treated with pRPLND.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16448","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:39:09Z","timestamp":1720179549000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary retroperitoneal lymph node dissection for metastatic non\u2010seminomatous germ cell tumours: outcomes and adjuvant chemotherapy"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-8048","authenticated-orcid":false,"given":"Ahmad","family":"Mousa","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"},{"name":"Division of Urology, Department of Surgery, Princess Margaret Cancer Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Anson\u2010Cartwright","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Princess Margaret Cancer Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eshetu G.","family":"Atenafu","sequence":"additional","affiliation":[{"name":"Biostatistics Core, University Health Network University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-5380","authenticated-orcid":false,"given":"Michael A.S.","family":"Jewett","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Princess Margaret Cancer Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Bedard","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di Maria","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Glicksman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padraig","family":"Warde","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Prendeville","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, Princess Margaret Cancer Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Comprehensive Cancer Network Testicular Cancer Guidelines (Version 1.2023).2023Nccnorg.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/testicular.pdf. Accessed January 2024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102925"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(99)00081-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00684866"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00118"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000792"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2022.11.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-199501000-00030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.04.082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.03.100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02712"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00289-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2006.0233"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07754.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.09.088"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.05.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02900-w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000318"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.044"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712033172303"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000020197"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.6.906"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm062"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991210)83:6<852::AID-IJC30>3.0.CO;2-S"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00014-A"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.1.69"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810301)47:5<840::AID-CNCR2820470503>3.0.CO;2-M"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.068"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90446-M"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90415-R"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:11:13Z","timestamp":1761754273000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/bju.16448"],"URL":"https:\/\/doi.org\/10.1111\/bju.16448","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}