{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:35:12Z","timestamp":1791822912021,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate alterations of homologous recombination repair (HRR) and especially BReast CAncer 1\/2 (\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2) gene on overall survival (OS). Moreover, to explore the effect of inhibition of poly(ADP\u2010ribose)\u2010polymerase (PARPi) as systemic therapy for metastatic castration\u2010resistant prostate cancer (mCRPC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      Of all HRR\u2010screened patients with metastatic prostate cancer, baseline characteristics were sampled. Kaplan\u2013Meier estimates and multivariable Cox regression models predicted the effect of HRR\/\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 alterations on OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 196 eligible patients, 61 (31%) harboured any HRR and 40 (20%)\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 alterations. Of HRR alterations, 40 (66%) vs six (10%) vs five (8.2%) vs four (6.6%) vs two (3.3%) vs four (6.6%) were\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 vs Ataxia\u2010telangiectasia mutated kinase (\n                      <jats:italic>ATM<\/jats:italic>\n                      ) vs checkpoint kinase 2 (\n                      <jats:italic>CHEK<\/jats:italic>\n                      2) vs cyclin\u2010dependent kinase 12 (\n                      <jats:italic>CDK<\/jats:italic>\n                      12) vs Fanconi anaemia complementation Group A (\n                      <jats:italic>FANCA<\/jats:italic>\n                      ) vs positive for other mutations. Of these, 30% received a PARPi. OS differed significantly between HRR\u2010positive vs \u2010negative patients. Specifically in hormone\u2010sensitive prostate cancer, the median OS was 63 (HRR positive) vs 57 (\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 positive) vs 113\u2009months (HRR negative) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.01). In mCRPC, OS was 42 (HRR positive) vs 41 (\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 positive) vs 70\u2009months (HRR negative) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.01). HRR and\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 alterations were associated with worse OS after multivariable adjustment. Finally, patients with mCRPC with\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 mutation treated without PARPi harboured worse OS than patients with\n                      <jats:italic>BRCA<\/jats:italic>\n                      1\/2 mutation and PARPi therapy (median OS: 33 vs 48\u2009months,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Incidence of HRR alteration in a clinical real\u2010world setting is high when using blood\u2010 and tissue\u2010based tests. Patients with HRR\/\n                      <jats:italic>BRCA<\/jats:italic>\n                      alterations have worse outcomes resulting in significant OS differences between HRR\/\n                      <jats:italic>BRCA<\/jats:italic>\n                      \u2010positive patients with mCRPC with and without PARPi usage vs HRR\/\n                      <jats:italic>BRCA<\/jats:italic>\n                      \u2010negative patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16462","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T04:00:05Z","timestamp":1720584005000},"page":"117-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impact of homologous recombination repair\/BReast CAncer (\n                    <scp>\n                      <i>BRCA<\/i>\n                      )\n                    <\/scp>\n                    gene alterations on survival in a real\u2010world setting of metastatic prostate cancer"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4338-0889","authenticated-orcid":false,"given":"Mike","family":"Wenzel","sequence":"first","affiliation":[{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Hoeh","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florestan","family":"Koll","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Humke","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fassl","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Reis","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wild","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt Goethe University Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Steuber","sequence":"additional","affiliation":[{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Graefen","sequence":"additional","affiliation":[{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-1380","authenticated-orcid":false,"given":"Derya","family":"Tilki","sequence":"additional","affiliation":[{"name":"Martini\u2010Klinik Prostate Cancer Center University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Urology University Hospital Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Department of Urology Koc University Hospital  Istanbul 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