{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:06:47Z","timestamp":1768781207313,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the association between cardiopulmonary exercise testing (CPET) and outcomes of radical cystectomy (RC), as RC is historically associated with high rates of short\u2010 and long\u2010term morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This quantitative systematic review and meta\u2010analysis was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis guidelines. An electronic literature search was conducted to identify all relevant studies evaluating the relationship between CPET parameters and RC outcomes. The primary outcome was short\u2010term mortality. Secondary outcomes included hospital length of stay (LOS) and rate of serious adverse events as defined by the Clavien\u2013Dindo classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search identified six studies for inclusion. A total of 546 patients underwent CPET prior to RC. There were significantly more deaths following RC observed in patients with poorer cardiopulmonary function (risk ratio RR 5.80, 95% confidence interval 4.96\u20136.78). There was no significant association between CPET parameters and adverse events or hospital LOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present systematic review and meta\u2010analysis identified a greater risk of 90\u2010day mortality in patients with poorer cardiorespiratory function, as measured by CPET. However, there remains a paucity of robust clinical data and further high\u2010quality studies are required to verify these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16476","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:46:12Z","timestamp":1726033572000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiopulmonary exercise testing prior to radical cystectomy: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9865-5738","authenticated-orcid":false,"given":"Allen Ao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Urology Royal North Shore Hospital  Sydney New South Wales Australia"},{"name":"North Shore Urology Research Group, Department of Urology Royal North Shore Hospital  Sydney New South Wales 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