{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:43:21Z","timestamp":1761745401223,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the impact of ejaculatory dysfunction (EjD; failure of emission or retrograde ejaculation) on health\u2010related quality of life (HRQoL) after retroperitoneal lymph node dissection (RPLND) for testicular cancer and explore the efficacy of pseudoephedrine hydrochloride as treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In a single arm, phase II trial, patients at \u22656\u2009months after RPLND were invited to complete patient\u2010reported outcome measures (European Organisation for Research and Treatment of Cancer [EORTC] quality of life questionnaire [QLQ]\u201030\u2010item core, EORTC QLQ\u2010testicular cancer\u201026, and Brief Male Sexual Function Inventory) evaluating HRQoL and sexual function in follow\u2010up (ACTRN12622000537752\/12622000542796). If EjD was reported, post\u2010ejaculatory urine \u00b1 semen analysis was undertaken. In eligible patients, pseudoephedrine hydrochloride 60\u2009mg was administered orally every 6\u2009h for six doses. The primary endpoint was sperm count &gt;39\u2009million sperm\/ejaculate (&gt;5th centile) following treatment. The trial was powered to detect a clinically relevant 36% achieving sperm count of &gt;39\u2009million sperm\/ejaculate. Secondary endpoints included semen volume &gt;1.5\u2009mL, total motile sperm count, safety, and HRQoL impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 58 patients enrolled, the median (interquartile range [IQR]) age was 35\u2009(29\u201341)\u2009years, with a median (IQR) of 37\u2009(18\u201360)\u2009months from RPLND. EjD was reported in 33 (57%), including 27\/52 (52%) receiving follow\u2010up at our centre. There were no differences in global HRQoL; however, role functioning (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.045), sexual problems (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.005), and sexual enjoyment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) was poorer if EjD was present. In all, 24\/33 (73%) patients with EjD consented to pseudoephedrine treatment. Of 22 evaluable patients, four (18%) achieved a sperm count of &gt;39\u2009million\/ejaculate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.20), and four (18%) had a semen volume of &gt;1.5\u2009mL (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.20). There was a mean increase of 105\u2009million sperm\/ejaculate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.051) and 1.47\u2009mL increase in semen volume (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). No safety concerns arose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ejaculatory dysfunction is common after RPLND but did not impact global HRQoL in our cohort. Pseudoephedrine improved EjD for some; however, its efficacy was lower than expected. Pseudoephedrine may be considered on an individualised basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16481","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T03:19:31Z","timestamp":1721791171000},"page":"805-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pseudoephedrine for ejaculatory dysfunction after retroperitoneal lymph node dissection in testicular cancer"],"prefix":"10.1111","volume":"134","author":[{"given":"Ciara","family":"Conduit","sequence":"first","affiliation":[{"name":"Medical Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Medical Oncology University of Melbourne  Melbourne Victoria Australia"},{"name":"Personalised Oncology Walter and Eliza Hall Institute of Medical Research  Melbourne Victoria Australia"},{"name":"Medical Oncology Royal Hobart Hospital  Hobart 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