{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:14:18Z","timestamp":1768868058164,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the influence of statins on the survival outcomes of patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC) treated with adjuvant intravesical bacille Calmette\u2010Gu\u00e9rin (BCG) immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A retrospective cohort of consecutive patients with NMIBC who received intravesical BCG therapy from 2001 to 2020 and statins prescription were identified. Overall survival (OS), cancer\u2010specific survival (CSS), recurrence\u2010free survival (RFS), and progression\u2010free survival (PFS) were analysed between the Statins Group vs No\u2010Statins Group using Kaplan\u2013Meier method and multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2602 patients with NMIBC who received intravesical BCG were identified. The median follow\u2010up was 11.0\u2009years. On Kaplan\u2013Meier analysis, the Statins Group had significant better OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), CSS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and PFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Subgroup analysis indicated statins treatment started before BCG treatment had better CSS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and PFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Upon multivariable Cox regression analysis, the \u2018statins before BCG\u2019 group was an independent protective factor for OS (hazard ratio [HR] 0.607, 95% confidence interval [CI] 0.514\u20130.716), and CSS (HR 0.571, 95% CI 0.376\u20130.868), but not RFS (HR 0.885, 95% CI 0.736\u20131.065), and PFS (HR 0.689, 95% CI 0.469\u20131.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Statins treatment appears to offer protective effects on OS and CSS for patients with NMIBC receiving adjuvant intravesical BCG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16493","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T02:41:38Z","timestamp":1726022498000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The potential benefits of concomitant statins treatment in\n                    <scp>patients with non\u2010muscle\u2010invasive bladder cancer<\/scp>"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-6534","authenticated-orcid":false,"given":"Kang","family":"Liu","sequence":"first","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Experimental and Clinical Biomedical Science University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-1484","authenticated-orcid":false,"given":"Hongda","family":"Zhao","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Chen","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1499-8372","authenticated-orcid":false,"given":"Peter Ka\u2010Fung","family":"Chiu","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"S.H. Ho Urology Centre, Department of Surgery, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-9048","authenticated-orcid":false,"given":"Renate","family":"Pichler","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura S.","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology (Urology) Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-0712","authenticated-orcid":false,"given":"Takafumi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-1933","authenticated-orcid":false,"given":"Luca","family":"Afferi","sequence":"additional","affiliation":[{"name":"Department of Urology Luzerner Kantonsspital  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-5706","authenticated-orcid":false,"given":"Andrea","family":"Mari","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-2457","authenticated-orcid":false,"given":"Satoshi","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-3035","authenticated-orcid":false,"given":"Juan Gomez","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Clinico San Carlos  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-0888","authenticated-orcid":false,"given":"Riccardo","family":"Campi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence  Florence Italy"},{"name":"Unit of Urological Robotic Surgery and Renal Transplantation, Careggi Hospital University of Florence  Florence Italy"},{"name":"European Association of Urology Young Academic Urologists Renal Cancer Working Group  Arnhem The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-1378","authenticated-orcid":false,"given":"Maria Carmen","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario La Ribera  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Rink","sequence":"additional","affiliation":[{"name":"Department of Urology Marienkrankenhaus Hamburg gGmbH  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2723","authenticated-orcid":false,"given":"Yair","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Texas Southwestern  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Roupr\u00eat","sequence":"additional","affiliation":[{"name":"Department of Urology, GRC 5 Predictive Onco\u2010Urology, AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Vienna  Vienna Austria"},{"name":"Karl Landsteiner Institute of Urology and Andrology  Vienna Austria"},{"name":"Department of Urology University of Texas Southwestern  Dallas TX USA"},{"name":"Department of Urology Weill Cornell Medical College  New York NY USA"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9361-2342","authenticated-orcid":false,"given":"Jeremy Yuen\u2010Chun","family":"Teoh","sequence":"additional","affiliation":[{"name":"S.H. 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