{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:34:04Z","timestamp":1788230044693,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess human\n                      <jats:italic>in vivo<\/jats:italic>\n                      intrarenal pressure (IRP) and peristaltic activity at baseline and after ureteric stent placement, using a narrow calibre pressure guidewire placed retrogradely in the renal pelvis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A prospective, multi\u2010institutional study recruiting consenting patients undergoing ureteroscopy was designed with ethical approval. Prior to ureteroscopy, the urinary bladder was emptied and the COMET\u2122 II pressure guidewire (Boston Scientific) was advanced retrogradely via the ureteric orifice to the renal pelvis. Baseline IRPs were recorded for 1\u20132\u2009min. At procedure completion, following ureteric stent insertion, IRPs were recorded for another 1\u20132\u2009min. Statistical analysis of mean baseline IRP, peristaltic waveforms and frequency of peristaltic contractions was performed, thereby analysing the influence of patient variables and ureteric stenting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 100 patients were included. Baseline mean (\u00b1SD) IRP was 16.76\u2009(6.4)\u2009mmHg in the renal pelvis, with maximum peristaltic IRP peaks reaching a mean (SD) of 25.75\u2009(17.9)\u2009mmHg. Peristaltic activity generally occurred in a rhythmic, coordinated fashion, with a mean (SD) interval of 5.63\u2009(3.08)\u2009s between peaks. On univariate analysis, higher baseline IRP was observed with male sex, preoperative hydronephrosis, and preoperative ureteric stenting. On linear regression, male sex was no longer statistically significant, whilst the latter two variables remained significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean (SD) baseline IRP in the non\u2010hydronephrotic, unstented cohort was 14.19\u2009(4.39)\u2009mmHg. Age, \u03b1\u2010blockers and calcium channel blockers did not significantly influence IRP, and no measured variables influenced peristaltic activity. Immediately after ureteric stent insertion, IRP decreased (mean [SD] 15.18\u2009[5.28] vs 16.76\u2009[6.4]\u2009mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004), whilst peristaltic activity was maintained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Human\n                      <jats:italic>in vivo<\/jats:italic>\n                      mean (SD) baseline IRP is 14.19\u2009(4.39)\u2009mmHg in normal kidneys and increases with both hydronephrosis and preoperative ureteric stenting. Mean (SD) peristaltic peak IRP values of 25.75\u2009(17.9)\u2009mmHg are reached in the renal pelvis every 3\u20137\u2009s and maintained in the early post\u2010stent period.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16497","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:31:16Z","timestamp":1722990676000},"page":"826-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Human\n                    <i>in vivo<\/i>\n                    baseline intrarenal pressure, peristaltic activity and response to ureteric stenting"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-3682","authenticated-orcid":false,"given":"Stefanie M.","family":"Croghan","sequence":"first","affiliation":[{"name":"Royal College of Surgeons Ireland (Strategic Academic Recruitment [StAR] Programme)  Dublin Ireland"},{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"},{"name":"Department of Urology Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-9040","authenticated-orcid":false,"given":"Eoghan M.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Bernal Institute, University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Health Research Institute, University of Limerick  Castletroy, Co. Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-5450","authenticated-orcid":false,"given":"Sorcha","family":"O\u2019Meara","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons Ireland (Strategic Academic Recruitment [StAR] Programme)  Dublin Ireland"},{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-0670","authenticated-orcid":false,"given":"Connor V.","family":"Cunnane","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Bernal Institute, University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Health Research Institute, University of Limerick  Castletroy, Co. Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Forde","sequence":"additional","affiliation":[{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"},{"name":"Department of Urology Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-744X","authenticated-orcid":false,"given":"Rustom P.","family":"Manecksha","sequence":"additional","affiliation":[{"name":"Department of Urology Tallaght University Hospital  Dublin Ireland"},{"name":"Department of Surgery Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Walsh","sequence":"additional","affiliation":[{"name":"School of Engineering University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Bernal Institute, University of Limerick  Castletroy, Co. Limerick Ireland"},{"name":"Health Research Institute, University of Limerick  Castletroy, Co. Limerick Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3891-5391","authenticated-orcid":false,"given":"Kieran J.","family":"Breen","sequence":"additional","affiliation":[{"name":"Department of Urology St. Michael's Hospital  Dublin Ireland"},{"name":"Department of Urology St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry B.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Department of Urology St. Michael's Hospital  Dublin Ireland"},{"name":"Department of Urology St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-8005","authenticated-orcid":false,"given":"Fergal J.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1475","authenticated-orcid":false,"given":"Niall F.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Urology Blackrock Clinic  Dublin Ireland"},{"name":"Department of Urology Beaumont Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365515309094217"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1926.02680160035011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15764"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16173"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(21)01211-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1114-4"},{"key":"e_1_2_10_8_1","volume-title":"Aspects of Renal Pelvic Function (Thesis)","author":"Djurhuus JC","year":"1980"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54269-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)66448-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03216-w"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010147"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00786"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-2049-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.138"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1985.tb07021.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-002-0258-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20097"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06346.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.09298.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.07.09"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2379-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.06.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365598109179612"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)32674-5"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:50:54Z","timestamp":1761731454000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/bju.16497"],"URL":"https:\/\/doi.org\/10.1111\/bju.16497","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]},"assertion":[{"value":"2024-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}