{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:32:17Z","timestamp":1794490337679,"version":"4.9.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse surgical, functional, and mid\u2010term oncological outcomes of robot\u2010assisted nephroureterectomy (RANU) in a contemporary large multi\u2010institutional setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Data were retrieved from the ROBotic surgery for Upper tract Urothelial cancer STtudy (ROBUUST) 2.0 database, an international, multicentre registry encompassing data of patients with upper urinary tract urothelial carcinoma undergoing curative surgery between 2015 and 2022. The analysis included all consecutive patients undergoing RANU except those with missing data in predictors. Detailed surgical, pathological, and postoperative functional data were recorded and analysed. Oncological time\u2010to\u2010event outcomes were: recurrence\u2010free survival (RFS), metastasis\u2010free survival (MFS), cancer\u2010specific survival (CSS), and overall survival (OS). Survival analysis was performed using the Kaplan\u2013Meier method, with a 3\u2010year cut\u2010off. A multivariable Cox proportional hazard model was built to evaluate predictors of each oncological outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1118 patients underwent RANU during the study period. The postoperative complications rate was 14.1%; the positive surgical margin rate was 4.7%. A postoperative median (interquartile range) estimated glomerular filtration rate decrease of \u221213.1\u2009(\u221227.5 to 0)\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      from baseline was observed. The 3\u2010year RFS was 59% and the 3\u2010year MFS was 76%, with a 3\u2010year OS and CSS of 76% and 88%, respectively. Significant predictors of worse oncological outcomes were bladder\u2010cuff excision, high\u2010grade tumour, pathological T stage \u22653, and nodal involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study contributes to the growing body of evidence supporting the increasing adoption of RANU. The procedure consistently offers low surgical morbidity and can provide favourable mid\u2010term oncological outcomes, mirroring those of open NU, even in non\u2010organ\u2010confined disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16526","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T08:14:50Z","timestamp":1726128890000},"page":"967-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Robot\u2010assisted nephroureterectomy: surgical and mid\u2010term oncological outcomes in over 1100 patients (ROBUUST 2.0 collaborative group)"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0126-4731","authenticated-orcid":false,"given":"Francesco","family":"Ditonno","sequence":"first","affiliation":[{"name":"Department of Urology Rush University  Chicago IL USA"},{"name":"Department of Urology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Urology Rush University  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-5207","authenticated-orcid":false,"given":"Zhenjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Changhai Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-0462","authenticated-orcid":false,"given":"Linhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Changhai Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Abdollah","sequence":"additional","affiliation":[{"name":"Vattikuti Urology Institute Henry Ford Hospital  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4868-9025","authenticated-orcid":false,"given":"Giuseppe","family":"Simone","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS \u201cRegina Elena\u201d National Cancer Institute  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres F.","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Urology Fox Chase Cancer Center  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-7858","authenticated-orcid":false,"given":"Matteo","family":"Ferro","sequence":"additional","affiliation":[{"name":"Division of Urology European Institute of Oncology (IEO)\u2010IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisto","family":"Perdon\u00e0","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori di Napoli IRCCS \u2018Fondazione G. 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