{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:21:52Z","timestamp":1791357712628,"version":"4.3.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n Objective<\/jats:title>\n To evaluate the relationship between renal pelvis pressure and infection after ureteroscopy, using a live swine model.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n In anaesthetised pigs, a 1\u2010h ureteroscopy was performed using a pressure\u2010sensing guidewire, with renal pelvis pressure maintained at either 37\u2009mmHg or 75\u2009mmHg for the entire procedure and infusion with saline alone or with a standardised concentration of uropathogenic\n Escherichia coli<\/jats:italic>\n strain CFT073 (1.5\u2009\u00d7\u200910\n 7<\/jats:sup>\n \u2009colony\u2010forming units [CFU]\/mL). Venous blood sampling was performed during and after the procedure. Vital signs, inflammatory biomarkers, and renal tissue and blood cultures were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In 21 pig kidneys, study groups were: 37\u2009mmHg with saline irrigation (\n n<\/jats:italic>\n \u2009=\u20093); 75\u2009mmHg with saline irrigation (\n n<\/jats:italic>\n \u2009=\u20094); 37\u2009mmHg with saline irrigation with 1.5\u2009\u00d7\u200910\n 7<\/jats:sup>\n \u2009CFU\/mL\n E.\u2009coli<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u20097); and 75\u2009mmHg with saline irrigation with 1.5\u2009\u00d7\u200910\n 7<\/jats:sup>\n \u2009CFU\/mL\n E.\u2009coli<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u20097). Statistically significant changes in inflammatory biomarkers were most pronounced in the group with 75\u2009mmHg saline irrigation\u2009+\u2009\n E. coli<\/jats:italic>\n and were significantly elevated compared with the control group and the group receiving\n E. coli<\/jats:italic>\n irrigation at 37\u2009mmHg. Positive blood cultures were noted in 5\/7 animals treated with\n E. coli<\/jats:italic>\n at 75\u2009mmHg; no others developed bacteraemia.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this swine model of ureteroscopy, irrigation with saline +\n E. coli<\/jats:italic>\n at a renal pelvis pressure of 75\u2009mmHg resulted in bacteraemia and inflammatory biomarker elevations significantly greater than both\n E. coli<\/jats:italic>\n irrigation with renal pelvis pressure maintained at 37\u2009mmHg and the control.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.16539","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T22:47:56Z","timestamp":1729810076000},"page":"279-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Relationship between renal pelvis pressure and post\u2010ureteroscopy infection in a live swine model"],"prefix":"10.1111","volume":"135","author":[{"given":"David","family":"Hinojosa\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Urology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kottooran","sequence":"additional","affiliation":[{"name":"Department of Urology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Saunders","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Chaussee","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation Marlborough MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Budrewicz","sequence":"additional","affiliation":[{"name":"CBSET Lexington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-4100","authenticated-orcid":false,"given":"Brian H.","family":"Eisner","sequence":"additional","affiliation":[{"name":"Department of Urology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.1133"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16029"},{"key":"e_1_2_8_4_1","first-page":"111","article-title":"Urology: the clinical significance of pyelovenous backflow","volume":"29","author":"Hinman F","year":"1928","journal-title":"Cal West Med"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2378-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15858"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1114-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.1998.12.45"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16095"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010147"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123429"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03450-2"},{"key":"e_1_2_8_13_1","first-page":"002","article-title":"Modified clinical monitoring assessment for multi\u2010organ failure during bacteremia and sepsis progression in a pig model","volume":"1","author":"Waterhouse A","year":"2018","journal-title":"Adv Crit Care Med"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:39:38Z","timestamp":1761748778000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/bju.16539"],"URL":"https:\/\/doi.org\/10.1111\/bju.16539","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}