{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:00:54Z","timestamp":1790128854829,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine the safety and oncological advantages of\n                      <jats:italic>en bloc<\/jats:italic>\n                      resection of bladder tumour (ERBT) vs conventional transurethral resection of bladder tumour (cTURBT) in terms of resection quality, staging quality, and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010blinded randomised controlled trial at seven European hospitals with the following inclusion criteria: first diagnosis of non\u2010muscle\u2010invasive bladder cancer, no singular carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      , and tumour size &gt;4.3\u2009mm. Patients were randomised intraoperatively in a 1:1 ratio to either the ERBT or cTURBT group. Outcome analysis was performed using the chi\u2010square test,\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, and multivariate regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 97 patients were randomised into the study (cTURBT\u2009=\u200940, ERBT\u2009=\u200957). A switch to cTURBT was necessary in two patients (3.5%) and 11.5% of the screened patients were preoperatively excluded for ERBT. There was no difference in the specimen presence of detrusor muscle with 73.7% in cTURBT and 67.3% in ERBT specimens (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.69). There were no significant differences in mean operative time (ERBT 27.6 vs cTURBT 25.4\u2009min,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.450) or mean resection time (ERBT 16.3 vs cTURBT 15.5\u2009min,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.732). Overall the complication rate did not differ significantly (ERBT 18.2% vs cTURBT 7.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.142). Bladder perforations occurred significantly more often in the ERBT group (ERBT seven vs cTURBT none,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.020). R0 status was reported more often after ERBT, whilst a second resection was significantly less frequent after ERBT (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018). Recurrence rates were comparable for both techniques after 6\u2009months of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The feasibility of ERBT is higher than previously reported. Whereas other perioperative and safety parameters are comparable to cTURBT, bladder perforations occurred significantly more often in the ERBT group and raised safety concerns. This is why this trial was terminated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16543","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T04:38:58Z","timestamp":1730003938000},"page":"446-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An international multicentre randomised controlled trial of\n                    <i>en bloc<\/i>\n                    resection of bladder tumour vs conventional transurethral resection of bladder tumour: first results of the\n                    <i>en bloc<\/i>\n                    resection of urothelium carcinoma of the bladder (\n                    <scp>EBRUC) II<\/scp>\n                    trial"],"prefix":"10.1111","volume":"135","author":[{"given":"Julian Peter","family":"Struck","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"},{"name":"Department of Urology Brandenburg Medical School Theodor Fontane (MHB)  Brandenburg an der Havel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-0626","authenticated-orcid":false,"given":"Nadim","family":"Moharam","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"},{"name":"Department of Urology and Urologic Surgery University Medical Centre Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Leitenberger","sequence":"additional","affiliation":[{"name":"Department of Urology Wolfsburg Hospital  Wolfsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Urology Wolfsburg Hospital  Wolfsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lusuardi","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Salzburg University Hospital  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Oswald","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Salzburg University Hospital  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Rassweiler","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology SLK\u2010Klinikum  Heilbronn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology SLK\u2010Klinikum  Heilbronn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Hor\u0148\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Urology of the 2nd Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Motol University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Babjuk","sequence":"additional","affiliation":[{"name":"Department of Urology of the 2nd Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Motol University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Micali","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedale Civile S. Agostino Estense  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Zaraca","sequence":"additional","affiliation":[{"name":"Department of Urology Ospedale Civile S. Agostino Estense  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Spreu","sequence":"additional","affiliation":[{"name":"Department of Urology Protest and Hospital K\u00f6nigin Elisabeth Herzberge  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Friedersdorff","sequence":"additional","affiliation":[{"name":"Department of Urology Protest and Hospital K\u00f6nigin Elisabeth Herzberge  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Borgmann","sequence":"additional","affiliation":[{"name":"Department of Urology Brandenburg Medical School Theodor Fontane (MHB)  Brandenburg an der Havel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel S.","family":"Merseburger","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario W.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"BabjukM BurgerM Comp\u00e9ratE GonteroP LiedbergF.EAU Guidelines on non\u2010muscle\u2010invasive bladder cancer (TaT1 and CIS).2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061448"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.4172"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13734"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.120"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.04.059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"e_1_2_9_9_1","volume-title":"ASA physical status classification system","author":"American Society of Anesthesiologists","year":"2020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.12.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15150"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.07.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.05.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.01.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2016.0534"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03675-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2604-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-015-1568-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04052-w"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03765-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22565"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:32:20Z","timestamp":1761744740000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,27]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/bju.16543"],"URL":"https:\/\/doi.org\/10.1111\/bju.16543","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,27]]},"assertion":[{"value":"2024-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}