{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:44:12Z","timestamp":1768682652083,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse the management and outcomes of individuals diagnosed with prostate cancer either before or after organ transplantation, as the impact of organ transplantation and associated immunosuppression on the incidence, progression, and mortality of prostate cancer remains an area of substantial clinical interest and uncertainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of patients from two tertiary care centres who had solid organ transplantation and were diagnosed with prostate cancer before or after organ transplantation. Data collected included demographics and clinical information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort consisted of 110 patients with a median (interquartile range [IQR]) age at prostate cancer diagnosis of 62\u2009(56.6\u201367.2)\u2009years and a median (IQR) age at transplantation of 58.6\u2009(52.7\u201365.3)\u2009years. Renal transplantation was the most common (54%). The median (IQR) prostate\u2010specific antigen concentration at prostate cancer diagnosis was 6.2\u2009(4.5\u201310)\u2009ng\/mL, and the distribution of American Urological Association risk groups was: low risk, 36%; intermediate risk, 50%; and high risk, 14%. In all, 45 (41%) patients were diagnosed with prostate cancer prior to transplantation. Management included radical prostatectomy (RP; 62%), prostate radiotherapy (RT; 13%), and active surveillance (AS; 18%). During a median (IQR) follow\u2010up of 5.8\u2009(2.5\u201310)\u2009years from prostate cancer diagnosis, one (2%) patient developed metastatic disease. In all, 65 (59%) patients were diagnosed with prostate cancer subsequent to organ transplantation. Management included AS (29%), RT (45%), and RP (15%). During a median (IQR) follow\u2010up of 5.3\u2009(1\u20138.4)\u2009years, three patients (5%) developed metastatic disease. There were no deaths from prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A diagnosis of localised prostate cancer should not preclude solid organ transplantation, and the presence of a transplant does not appear to substantially impact risk of prostate cancer progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16558","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T09:25:18Z","timestamp":1728552318000},"page":"339-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prostate cancer and solid organ transplantation: patient management and outcomes"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-5319","authenticated-orcid":false,"given":"Alon","family":"Lazarovich","sequence":"first","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya W.","family":"Kristof","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shavano","family":"Steadman","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan  Ann\u2010Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Dahmen","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-0794","authenticated-orcid":false,"given":"Michelle A.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Department of Medicine University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Barth","sequence":"additional","affiliation":[{"name":"Section of Transplant Surgery, Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan  Ann\u2010Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Olivier","family":"Timsit","sequence":"additional","affiliation":[{"name":"Department of Urology and Transplant Surgery, AP\u2010HP Universit\u00e9 de Paris\/H\u00f4pital Europ\u00e9en Georges\u2010Pompidou  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Eggener","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"No Title [Internet].https:\/\/unos.org\/news\/2022\u2010organ\u2010transplants\u2010again\u2010set\u2010annual\u2010records\/"},{"key":"e_1_2_9_3_1","first-page":"85","article-title":"Prostate cancer screening and management in solid organ transplant candidates and recipients","volume":"21","author":"Becher E","year":"2019","journal-title":"Rev 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