{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:41:39Z","timestamp":1776357699193,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To conduct a population\u2010based study examining cancer\u2010specific mortality (CSM) and other\u2010cause mortality (OCM) differences in patients with radiation\u2010induced secondary bladder cancer (RT\u2010BCa) vs those with primary bladder cancer (pBCa) undergoing radical cystectomy (RC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Within the Surveillance, Epidemiology, and End Results database (2004\u20132020), we identified patients with T\n                      <jats:sub>2\u20134<\/jats:sub>\n                      N\n                      <jats:sub>0\u20133<\/jats:sub>\n                      M\n                      <jats:sub>0<\/jats:sub>\n                      bladder cancer treated with RC, who had previously been treated with external beam radiation therapy (EBRT) or brachytherapy for prostate cancer, as well as patients with T\n                      <jats:sub>2\u20134<\/jats:sub>\n                      N\n                      <jats:sub>0\u20133<\/jats:sub>\n                      M\n                      <jats:sub>0<\/jats:sub>\n                      pBCa treated with RC. Cumulative incidence plots and multivariable competing risks regression (CRR) models were used to assess CSM after additional adjustment for OCM. The same methodology was then repeated based on organ\u2010confined (OC: T\n                      <jats:sub>2<\/jats:sub>\n                      N\n                      <jats:sub>0<\/jats:sub>\n                      M\n                      <jats:sub>0<\/jats:sub>\n                      ) and non\u2010organ\u2010confined (NOC: T\n                      <jats:sub>3\u20134<\/jats:sub>\n                      and\/or N\n                      <jats:sub>1\u20133<\/jats:sub>\n                      ) disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 9957 RC patients, RT\u2010BCa was identified in 347 (3%) compared with 9610 (97%) who had pBCa. In multivariable CRR models, no CSM differences were recorded in the overall comparison (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8), nor in sub\u2010groups based on OC and NOC disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8 and 0.7, respectively). Conversely, multivariable CRR models identified RT\u2010BCa as an independent predictor of 1.3\u2010fold higher OCM in the overall cohort and of 1.5\u2010fold higher OCM in those with NOC disease. In a sensitivity analysis of patients with NOC disease, EBRT was associated with higher OCM rates (hazard ratio 1.5). By contrast, OCM rates were not different in those with OC disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed that RC for RT\u2010BCa was associated with similar CSM rates as RC for pBCa, regardless of disease stage. However, patients who had undergone EBRT exhibited significantly higher OCM in the NOC sub\u2010group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16571","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T01:04:52Z","timestamp":1730077492000},"page":"596-602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mortality rates in radical cystectomy patients with bladder cancer after radiation therapy for prostate cancer"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0494-7839","authenticated-orcid":false,"given":"Mario","family":"de Angelis","sequence":"first","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"},{"name":"Division of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-4171","authenticated-orcid":false,"given":"Carolin","family":"Siech","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"},{"name":"Frankfurt Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-3701","authenticated-orcid":false,"given":"Francesco","family":"Di Bello","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3057-3805","authenticated-orcid":false,"given":"Natali","family":"Rodriguez Pe\u00f1aranda","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"},{"name":"Department of Urology, AOU di Modena University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4609-8981","authenticated-orcid":false,"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K.H.","family":"Chun","sequence":"additional","affiliation":[{"name":"Frankfurt Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1597-9595","authenticated-orcid":false,"given":"Stefano","family":"Puliatti","sequence":"additional","affiliation":[{"name":"Department of Urology, AOU di Modena University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-5617","authenticated-orcid":false,"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Urology, Cancer Prognostics and Health Outcomes Unit University of Montr\u00e9al Health Center  Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medical College  New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Hourani Center of Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"},{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Moschini","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Longoni","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology, URI IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan 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