{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T15:56:32Z","timestamp":1772294192621,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003510","name":"Wilson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non\u2010coding RNA (lncRNA)\u2010based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Transcriptome\u2010wide expression profiling using Decipher Bladder was performed on transurethral resection of bladder tumour samples from a cohort of patients with high\u2010grade, clinically organ\u2010confined (cTa\u2013T2N0M0) urothelial carcinoma (UC) who subsequently underwent RC without any neoadjuvant therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009226). The lncRNA\u2010based luminal favourable status was determined using a previously developed GC. The primary endpoint was overall survival (OS) after RC. Secondary endpoints included cancer\u2010specific mortality and upstaging at RC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the study, 134 patients were clinical non\u2010muscle\u2010invasive bladder cancer (cTa\/Tis\/T1) and 92 patients were cT2. We identified 60 patients with luminal favourable subtype, all of which showed robust gene expression patterns associated with less aggressive bladder cancer biology. On multivariate analysis, patients with the luminal favourable subtype (vs without) were significantly associated with lower odds of upstaging to pathological (p)T3+ disease (odds ratio [OR] 0.32, 95% confidence interval [CI] 0.12\u20130.82;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), any upstaging (OR 0.41, 95% CI 0.20\u20130.83;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01), and any upstaging and\/or pN+ (OR 0.50, 95% CI 0.25\u20131.00;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05). Luminal favourable bladder cancer was significantly associated with better OS (hazard ratio 0.33, 95% CI 0.15\u20130.74;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study validates the performance of the GC for identifying UCs with a luminal favourable subtype, harbouring less aggressive tumour biology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16572","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T09:30:24Z","timestamp":1730453424000},"page":"648-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A luminal non\u2010coding RNA\u2010based genomic classifier confirms favourable outcomes in patients with clinically organ\u2010confined bladder cancer treated with radical cystectomy"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-367X","authenticated-orcid":false,"given":"Joep J.","family":"de Jong","sequence":"first","affiliation":[{"name":"Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Proudfoot","sequence":"additional","affiliation":[{"name":"Veracyte Inc.  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"Department of Urology, USC\/Norris Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Svatek","sequence":"additional","affiliation":[{"name":"University of Texas Health San Antonio  San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Narayan","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewan A.","family":"Gibb","sequence":"additional","affiliation":[{"name":"Veracyte Inc.  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elai","family":"Davicioni","sequence":"additional","affiliation":[{"name":"Veracyte Inc.  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreyas","family":"Joshi","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Dahmen","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-7200","authenticated-orcid":false,"given":"Roger","family":"Li","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-4485","authenticated-orcid":false,"given":"Brant A.","family":"Inman","sequence":"additional","affiliation":[{"name":"Western University  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paras","family":"Shah","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftach","family":"Chaplin","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Wright","sequence":"additional","affiliation":[{"name":"University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2723","authenticated-orcid":false,"given":"Yair","family":"Lotan","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern  Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.10.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002261"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.02.028"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.09.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025915"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0669-z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JU.0001009500.87761.bf.07"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.030"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3558"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5903"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy088"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.05.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-019-0262-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20481"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-0792"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-1283"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26421-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/2056-4538.12363"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.TPS4623"},{"key":"e_1_2_10_24_1","first-page":"S1506","article-title":"First safety and efficacy results of the tar\u2010210ERDAFITINIB intravesical delivery system in patientswith non\u2010muscle\u2010invasive bladder cancer with select FGFR alterations","volume":"85","author":"Vilaseca A","year":"2024","journal-title":"AUA"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:10:30Z","timestamp":1761750630000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/bju.16572"],"URL":"https:\/\/doi.org\/10.1111\/bju.16572","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}