{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:10:35Z","timestamp":1774977035298,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To define the natural history, patterns of recurrence and treatment modalities for local prostate cancer (PCa) recurrence following radical prostatectomy (RP) and radiation therapy (RT), and to investigate factors that could predict metastasis\u2010free survival (MFS) in this unique patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried a prospectively maintained PCa registry to identify men developing in\u2010field recurrence (IFR) following RP and RT from 2008 to 2021 at a single institution. IFR was defined as biopsy\u2010proven recurrent PCa or the presence of persistent positron emission tomography\u2010avid lesions in the prior radiation field without evidence of metastasis. Cox regression was conducted to determine predictors of MFS. Kaplan\u2013Meier methods were used to calculate MFS, cancer\u2010specific survival (CSS) and overall survival (OS) for patients in three primary therapy categories: cryoablation, androgen deprivation therapy (ADT) alone, and surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 4575 patients from our registry, 108 (2.3%) with IFR were identified. The median (interquartile range [IQR]) time to IFR from salvage treatment was 78\u2009(50\u2013126) months. A total of 29 patients (26%) were managed with cryoablation, 23 (21%) with ADT, and 28 (25%) with surveillance. The median (IQR) follow\u2010up was 76\u2009(48\u2013100) months. There were no statistically significant differences in MFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.67) or OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.07) among the three primary treatment cohorts. Patients treated with ADT or cryoablation had longer CSS compared to patients managed with surveillance (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that IFR may present years after completion of primary treatment for PCa. While curative management strategies may be attempted, local and distant metastatic recurrence is common and often requires systemic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16598","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T05:35:00Z","timestamp":1732944900000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In\u2010field prostate cancer recurrence following radical prostatectomy and salvage radiation"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4921-0900","authenticated-orcid":false,"given":"Austin","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Britton","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8183-8047","authenticated-orcid":false,"given":"Anthony","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Childs","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance","family":"Mynderse","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-6866","authenticated-orcid":false,"given":"Derek","family":"Lomas","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Woodrum","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Frendl","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Karnes","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew K.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene D.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack R.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic  Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Cancer Society.Cancer Statistics Center. 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