{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:34:50Z","timestamp":1792128890174,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate changes in quality of life (QoL) up to 8\u2009years after radical cystectomy (RC) and compare QoL after RC with a gender\u2010 and age\u2010matched Dutch normative population. Furthermore, we aimed to identify patient characteristics associated with QoL and QoL trajectories after RC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients with bladder cancer were invited to complete QoL questionnaires at 3\u2010month intervals in the first year and yearly thereafter. Follow\u2010up data were available for a maximum of 8\u2009years. We used linear mixed\u2010effect models to investigate changes in QoL subscales (physical functioning [PF], emotional functioning [EF], and QoL summary score [QoL\u2010sum]) over time, and to identify potential demographic and clinical correlates of QoL and QoL trajectories (i.e., interaction with time).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 278 patients was included. Post\u2010RC EF scores increased from 83.7 (95% confidence interval [CI] 81.7\u201385.6) to levels comparable to the normative population (90.1) 8\u2009years after RC. PF (post\u2010RC: 82.4, 95% CI 78.5\u201386.3) and QoL\u2010sum (post\u2010RC: 88.2, 95% CI 85.2\u201391.2) remained lower compared to the normative population (88.9 and 91.4, respectively) 8\u2009years after RC. Compared to patients with an American Society of Anesthesiologists (ASA) score of 1 at diagnosis, those with ASA score 2 or ASA score 3 had significant lower post\u2010RC PF (mean difference (MD)\u2009=\u2009\u22128 and \u221222, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), EF (MD\u2009=\u2009\u22121 and \u221211;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.5 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and QoL\u2010sum (MD\u2009=\u2009\u22122 and \u22129;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.2 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). In addition, patients with a higher ASA score had a worse QoL\u2010sum trajectory (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u2009=\u20090.01). Older patients had a worse PF trajectory (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u2009&lt;\u20090.01) but higher post\u2010RC EF (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Directly after RC, patients have lower PF, EF and QoL\u2010sum, compared to a normative population. Notably, EF recovers to normative levels over a period of 8\u2009years after RC. Clinicians are encouraged to administer supportive care interventions to enhance the QoL for patients undergoing RC, especially targeting older patients and those with higher ASA scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16610","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T18:40:01Z","timestamp":1733078401000},"page":"675-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term quality of life in patients with bladder cancer following radical cystectomy"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-5242","authenticated-orcid":false,"given":"Emine","family":"Akdemir","sequence":"first","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Center for Quality of Life The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn M.","family":"Stuiver","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Center for Quality of Life The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Epidemiology and Data Science Amsterdam UMC  AMC The Netherlands"},{"name":"Centre of Expertise Urban Vitality, Faculty of Health Amsterdam University of Applied Sciences  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike W.","family":"van de Kamp","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda Bloos \u2010 van","family":"der Hulst","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"Hendricksen","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim H.","family":"van Harten","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Health Technology and Services Research University of Twente  Enschede The Netherlands"},{"name":"Rijnstate Hospital  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"May","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike G.","family":"Sweegers","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Center for Quality of Life The Netherlands Cancer Institute  Amsterdam The 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