{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:35:58Z","timestamp":1790030158330,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker\u2010negative non\u2010seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data from 17 institutions were collected, comprising 305 men who underwent primary RPLND for CS 2 NSGCT. Regression analyses were conducted to predict histology in the RPLND specimen and disease\u2010free survival (DFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A larger retroperitoneal lymph node diameter was associated with pure teratoma in the RPLND specimen (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.01\u20131.07;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03), but no association was observed with DFS. The 5\u2010year DFS rates in marker negative CS 2a and 2b were 79% and 76%. In men with non\u2010teratomatous viable cancer in the RPLND specimen, the 5\u2010year DFS rates for CS 2a and 2b were 95% and 87% with adjuvant chemotherapy, and 67% and 74% without adjuvant chemotherapy. We did not identify an association between the number of adjuvant chemotherapy cycles and DFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests considering primary RPLND not only in marker\u2010negative CS 2a but also in CS 2b. Further research should determine the efficacy of primary RPLND in men with CS 2c and marker\u2010positive CS 2, as well as which patients may benefit from adjuvant chemotherapy and the optimal cycle number.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16618","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:55:16Z","timestamp":1733946916000},"page":"621-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary retroperitoneal lymph node dissection in clinical stage 2a\/b non\u2010seminomatous germ cell tumour"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6067-5497","authenticated-orcid":false,"given":"Luca","family":"Antonelli","sequence":"first","affiliation":[{"name":"Department of Urology, Luzerner Kantonsspital University of Lucerne  Lucerne Switzerland"},{"name":"Department of Urology, Policlinico Umberto I Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-3664","authenticated-orcid":false,"given":"Axel","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Urology, Uro\u2010Oncology, Robot Assisted and Reconstructive Urologic Surgery, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Urology Medical University  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bagrodia","sequence":"additional","affiliation":[{"name":"Department of Urology Univerity of California  San Diego CA USA"},{"name":"The University of Texas Southwestern  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armon","family":"Amini","sequence":"additional","affiliation":[{"name":"Department of Urology Univerity of California  San Diego CA USA"},{"name":"The University of Texas Southwestern  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Baky","sequence":"additional","affiliation":[{"name":"Department of Urology Univerity of California  San Diego CA USA"},{"name":"The University of Texas Southwestern  Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Branger","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology 2 Institut Paoli\u2010Calmettes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Department of Urology The Royal Marsden NHS Foundation Trust  London Sutton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.","family":"Clinton","sequence":"additional","affiliation":[{"name":"Department of Urology Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-9598","authenticated-orcid":false,"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"Institute of Urology, Kenneth Norris Jr. Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-3556","authenticated-orcid":false,"given":"Hooman","family":"Djaladat","sequence":"additional","affiliation":[{"name":"Institute of Urology, Kenneth Norris Jr. Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Eggener","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-7240","authenticated-orcid":false,"given":"Alireza","family":"Ghoreifi","sequence":"additional","affiliation":[{"name":"Institute of Urology, Kenneth Norris Jr. Comprehensive Cancer Center University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ho","sequence":"additional","affiliation":[{"name":"Section of Urology, Department of Surgery University of Chicago Medical Center  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade J.","family":"Sexton","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology H. 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