{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:27:32Z","timestamp":1783826852132,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between prostate\u2010specific antigen (PSA) density (PSAD) and prostate cancer mortality after a benign result on systematic transrectal ultrasonography (TRUS)\u2010guided prostate biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study used data from the Finnish Randomised Study of Screening for Prostate Cancer (FinRSPC) collected between 1996 and 2020. We identified men aged 55\u201371\u2009years randomised to the screening arm with PSA \u22654.0\u2009ng\/mL and a benign systematic TRUS\u2010guided biopsy result. The cumulative prostate cancer mortality of men stratified by a PSAD cutoff of 0.15\u2009ng\/mL\/cm\n                      <jats:sup>3<\/jats:sup>\n                      was modelled with competing risk functions. The ability of PSAD, PSA, and base variables (age at biopsy, DRE result, socioeconomic status, 5\u03b1\u2010reductase inhibitor usage, family history, and Charlson Comorbidity Index (CCI)) to predict prostate cancer death was compared using\n                      <jats:italic>c<\/jats:italic>\n                      \u2010statistics and a likelihood ratio test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After excluding 10 men without PSA data within 2\u2009years of the biopsy and 65 without prostate volume data, 2276 men were eligible for inclusion in the study. A total of 50 men died from prostate cancer and 1028 from other causes during a median (interquartile range) follow\u2010up of 17.4\u2009(13.2\u201320.9)\u2009years. The cumulative prostate cancer mortality of men with PSAD &lt;0.15\u2009ng\/mL\/cm\n                      <jats:sup>3<\/jats:sup>\n                      was significantly lower than that of men with PSAD \u22650.15\u2009ng\/mL\/cm\n                      <jats:sup>3<\/jats:sup>\n                      : 0.5% (95% confidence interval [CI] 0.2%\u20131.1%) vs 2.0% (95% CI 1.2%\u20133.1%) at 15\u2009years (Grey's test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). The model consisting of PSAD, PSA and the base variables predicted prostate cancer mortality (\n                      <jats:italic>c<\/jats:italic>\n                      \u2010statistic 0.781) significantly better than either the base variables alone (\n                      <jats:italic>c<\/jats:italic>\n                      \u2010statistic 0.737; likelihood\u2010ratio test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003) or the base variables and PSA (\n                      <jats:italic>c<\/jats:italic>\n                      \u2010statistic 0.765; likelihood\u2010ratio test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prostate cancer mortality after a benign systematic TRUS\u2010guided biopsy is low. In these patients, PSAD predicts prostate cancer mortality and provides additional value to other clinical variables. PSAD\u2010based stratification can be used to guide follow\u2010up strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16641","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:47:46Z","timestamp":1737524866000},"page":"841-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of prostate\u2010specific antigen density with prostate cancer mortality after a benign systematic prostate biopsy result"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-3759","authenticated-orcid":false,"given":"Juho","family":"Pylv\u00e4l\u00e4inen","sequence":"first","affiliation":[{"name":"Department of Radiology, HUS Diagnostic Centre Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-9265","authenticated-orcid":false,"given":"Kirsi","family":"Talala","sequence":"additional","affiliation":[{"name":"Cancer Society of Finland  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-0978","authenticated-orcid":false,"given":"Jani","family":"Raitanen","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences (Health Sciences), Prostate Cancer Research Center Tampere University  Tampere Finland"},{"name":"UKK Institute for Health Promotion Research  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-3484","authenticated-orcid":false,"given":"Antti","family":"Rannikko","sequence":"additional","affiliation":[{"name":"Department of Urology Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-4818","authenticated-orcid":false,"given":"Anssi","family":"Auvinen","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences (Health Sciences), Prostate Cancer Research Center Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"EAU Guidelines.Edn. presented at the EAU annual congress Milan 2023. 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