{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:18:46Z","timestamp":1792703926239,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the oncological efficacy and safety of sequential intravesical gemcitabine\/docetaxel (Gem\/Doce) therapy in a European cohort of patients with high\u2010risk and very\u2010high\u2010risk non\u2010muscle\u2010invasive bladder cancer (NMIBC) after previous Bacillus Calmette\u2013Gu\u00e9rin (BCG) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data were retrospectively collected from 95 patients with NMIBC, treated with Gem\/Doce at 12 European centres between 2021 and 2024. Patients previously treated with BCG who had completed a full induction course and received at least one follow\u2010up evaluation were included. One\u2010year disease\u2010free survival (DFS), high\u2010grade DFS and progression\u2010free survival (PFS) were estimated using Kaplan\u2013Meier curves. Adverse events (AEs) were recorded through medical interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 75 patients, 63 (84%) were classified as having high\u2010risk and 12 (16%) as having very\u2010high\u2010risk NMIBC. Over a median (interquartile range) follow\u2010up of 9 (5\u201314) months, 20 patients (27%) relapsed and five (6.7%) underwent radical cystectomy. The 1\u2010year DFS was 73% (95% confidence interval [CI] 62\u201386%), 1\u2010year high\u2010grade DFS was 79% (95% CI 68\u201391%) and 1\u2010year PFS was 95% (95% CI 90\u2013100%). AEs occurred in 34 patients (45%), with six (8.7%) experiencing severe AEs. Limitations of the study include the short follow\u2010up and variability in both treatment dwelling times and dosage across centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intravesical Gem\/Doce regimen demonstrated promising short\u2010term oncological outcomes and was well tolerated in this cohort of patients with high\u2010 and very\u2010high\u2010risk NMIBC previously treated with BCG. Prospective studies and randomised trials are awaited to define the ideal candidates for Gem\/Doce therapy and to standardise treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16645","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T03:14:24Z","timestamp":1736565264000},"page":"969-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Gemcitabine and docetaxel for high\u2010risk non\u2010muscle\u2010invasive bladder cancer:\n                    <scp>EuroGemDoce<\/scp>\n                    group results"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6126-9889","authenticated-orcid":false,"given":"Pietro","family":"Scilipoti","sequence":"first","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele 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