{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:48Z","timestamp":1787013948272,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess 30\u2010 and 90\u2010day postoperative complication rates in patients who underwent robot\u2010assisted radical cystectomy (RARC) after receiving novel immunotherapy\u2010based neoadjuvant treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A bi\u2010centre analysis was conducted in patients who underwent RARC with intracorporeal urinary diversion and who received an immunotherapy\u2010based neoadjuvant regimen between 2017 and 2023. Complications were classified using the Clavien\u2013Dindo system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 136 patients, with a median (interquartile range [IQR]) age of 66\u2009(61\u201373) years, of whom 22 were female (16.2%). The overall 30\u2010day and 31\u201390\u2010day Clavien\u2013Dindo grade \u22653a complication rates were 15.4%, and 14.7%, respectively. The most common cumulative 90\u2010day complications by category were infectious (59.6%), genitourinary (33.1%), and gastrointestinal (22.7%). The median (IQR) hospital stay was 11 (7\u201316) days, and 36 patients (26.5%) required readmission. Eighty\u2010four patients received monotherapy with an immune checkpoint inhibitor and 52 received combination immunochemotherapy. A higher rate of 30\u2010day infectious complications was seen in the immuno\u2010monotherapy group (46.4% vs 26.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03), while pulmonary complications were more commonly reported in the combination immunochemotherapy group (9.6% vs 1.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). No statistically significant differences were found in the other complication categories between the groups. Eleven patients (8.1%) experienced 13 (9.6%) immune\u2010related adverse events (irAEs). The most common irAEs were hypothyroidism and dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The cumulative 90\u2010day complication rate after novel immunotherapy\u2010based neoadjuvant treatment appears higher than those previously reported for RARC alone or for chemotherapy\u2010based neoadjuvant regimens. We observed irAEs in 8.1% of patients after RARC, highlighting the need for urologists to recognise such events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16662","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T04:49:59Z","timestamp":1737607799000},"page":"321-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immunotherapy\u2010based neoadjuvant treatment and complication rates after radical cystectomy"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-7145","authenticated-orcid":false,"given":"Reuben","family":"Ben\u2010David","sequence":"first","affiliation":[{"name":"Urology Department Icahn School of Medicine at Mount Sinai Hospital  New York NY 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