{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:14:45Z","timestamp":1784139285607,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the 12\u2010year survival outcomes of patients with non\u2010muscle\u2010invasive bladder cancer (NMIBC) who underwent robot\u2010assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD), focusing on those upstaged to \u2265pT2 or with node\u2010positive disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A multicentre, prospectively maintained database (2004\u20132022) was reviewed to identify patients who had undergone RARC. Univariable and multivariable models were used to assess upstaging (\u2265pT2, \u2265pN1), and Kaplan\u2013Meier curves were used to predict cancer\u2010specific survival (CSS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 355 patients with NMIBC (295 men, 60 women), 12.68% had pT2, 8.2% had pT3, 4.2% had pT4, 5.4% had pN1, and 2.8% had pN2 disease. Age\u2009\u2265\u200983\u2009years (odds ratio [OR] 19.7), presence of carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      (CIS), in combination with Ta\/ T1 bladder cancer (OR 2.7), squamous cell carcinoma (OR 6.6), and variant histology (OR 6.2), predicted upstaging. A body mass index \u226528 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR 0.4) and Tis alone (OR 0.1) reduced upstaging. The OS rate for the entire cohort was 93% at 1\u2009year, 87% at 5\u2009years and 49% at 12\u2009years. The CSS rate was 97% at 1\u2009year, 83% at 5\u2009years and 76% at 12\u2009years. At 12\u2009years, OS was better in the non\u2010upstaged cohort (52%, 95% confidence interval [CI] 37%\u201374%) vs the upstaged cohort (39%, 95% CI 26%\u201357%). CSS was higher in the non\u2010upstaged cohort (79%, 95% CI 71%\u201388%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) vs the upstaged cohort (68%, 95% CI 56%\u201382%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides the longest follow\u2010up data on RARC in NMIBC. The presence of CIS, variant histology, and pT1 on transurethral resection of the bladder tumour were predictors of upstaging, which correlated with higher recurrence and worse survival. RARC with ICUD is a minimally invasive option for NMIBC patients who need to undergo early cystectomy, offering comparable long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16686","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T23:45:37Z","timestamp":1740095137000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term multicentre analysis of robot\u2010assisted radical cystectomy for non\u2010muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-0486","authenticated-orcid":false,"given":"Neeraja","family":"Tillu","sequence":"first","affiliation":[{"name":"Department of Urology Icahn School of Medicine at Mount Sinai  New York New York 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