{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:09:48Z","timestamp":1777748988241,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the incidence of acute kidney injury (AKI) and acute kidney disease (AKD) following radical cystectomy (RC) in patients with muscle\u2010invasive bladder cancer (BCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A consecutive cohort of 840 patients undergoing RC for muscle\u2010invasive BCa at a tertiary institution (2010\u20132022) was analysed. Clinical variables, comorbidities, surgical techniques and oncological regimens were recorded pre\u2010 and post\u2010surgery. Serum creatinine and estimated glomerular filtration rate (eGFR) were assessed at baseline, at 24, 48 and 72\u2009h, and 6\u2009days post\u2010surgery for AKI, and at multiple intervals up to 60\u2009days for AKD. Chronic kidney disease (CKD) stages G1 G2 and \u2265G3 were classified according to the Kidney Disease Improving Global Outcomes (KDIGO)\u2009guidelines. A multivariable logistic regression model was used to predict postoperative AKI or AKD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the patients included in the study, 33% developed AKI and 54% developed AKD. Independent predictors included advanced age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.03\u20131.08), chronic hypertension (OR 1.43, 95% CI 1.03\u20132.00) and Charlson Comorbidity Index \u22652 (OR 1.59, 95% CI 1.09\u20132.33). Surgical factors, including use of a robot\u2010assisted approach (OR 2.28, 95% CI 1.50\u20133.49) and ileal neobladder diversion (OR 1.84, 95% CI 1.05\u20133.24) were significant, possibly due to the associated prolonged operating times and metabolic challenges. Baseline renal function (CKD \u2265G3, OR 2.17, 95% CI 1.28\u20133.68) and lower preoperative eGFR strongly correlated with AKD risk; a baseline eGFR below 20\u2009mL\/min was associated with an AKD risk \u226580%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results showed that AKI and AKD are frequent complications of RC for muscle\u2010invasive BCa. Personalised nephrological counselling pre\u2010 and post\u2010surgery is essential to minimise morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16696","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:58:37Z","timestamp":1742727517000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute kidney disease after radical cystectomy for bladder cancer: a new onco\u2010nephrological view"],"prefix":"10.1111","volume":"136","author":[{"given":"Francesco","family":"Trevisani","sequence":"first","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI, IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Biorek srl  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Floris","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis, and Transplantation ARNAS G. Brotzu  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Longoni","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI, IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Rosiello","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI, IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Malvestiti","sequence":"additional","affiliation":[{"name":"Division of Experimental Oncology\/Unit of Urology URI, IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan 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