{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:30:32Z","timestamp":1788917432901,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the performance of Bladder Epicheck\u00ae (BE; Nucleix Ltd., Rehovot, Israel) in predicting tumour recurrence and bacillus Calmette\u2013Gu\u00e9rin (BCG) failure during the first year after induction treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Prospective study including 65 patients with non\u2010muscle\u2010invasive bladder cancer treated with BCG between 2018 and 2021. Urine samples analysed with BE were collected before and after BCG induction. Logistic binary regression was used to assess the association between clinical and pathological variables and BE results with tumour recurrence and BCG failure during the first year after induction treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up, 16 (24.6%) patients experienced a bladder cancer event, 11 (68.8%) of which were BCG failure (high\u2010grade recurrence) and five (31.2%) were low\u2010grade recurrences. The median (range) time to overall recurrence was 7.3\u2009(3.8\u201317.4)\u2009months. A significant association was found between the risk of tumour recurrence\/BCG failure and post\u2010BCG cystoscopy (odds ratio [OR] 10.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and OR 13.1;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively), post\u2010BCG BE result (OR 16.9;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 and OR 33.1;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively) and pre\/post\u2010BCG EpiScore value variation (OR 14.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001 and OR 7.1;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018, respectively). A nomogram including these three variables outperformed the Club Urol\u00f3gico Espa\u00f1ol de Tratamiento Oncol\u00f3gico (CUETO) risk tables to predict any bladder cancer event after BCG induction (area under the curve 95.1% vs 67.1%). Result validation in a larger and independent series is needed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The BE post\u2010BCG status and variations in EpiScore values can help us identify patients at higher risk of any bladder cancer event and BCG failure promptly. These data can have an impact on disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16697","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:18:22Z","timestamp":1741713502000},"page":"682-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bladder\n                    <scp>EpiCheck<\/scp>\n                    clinical utility to predict\n                    <scp>BCG<\/scp>\n                    response in non\u2010muscle\u2010invasive bladder cancer"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-922X","authenticated-orcid":false,"given":"Fiorella L.","family":"Rold\u00e1n","sequence":"first","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Ingelmo\u2010Torres","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5710-958X","authenticated-orcid":false,"given":"Claudia","family":"Mercader","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Figueras","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Padull\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Angeles","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep L.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Unitat de Bioestad\u00edstica, Departament de Fonaments Cl\u00ednics, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Ribal","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Franco","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-2987","authenticated-orcid":false,"given":"Laura","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Alcaraz","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Mengual","sequence":"additional","affiliation":[{"name":"Laboratori i Servei d'Urologia Hospital Clinic de Barcelona  Barcelona Spain"},{"name":"Gen\u00e8tica i Tumors Urol\u00f2gics Fundaci\u00f3 de Recerca Clinic Barcelona\u2010Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (FRCB\u2010IDIBAPS)  Barcelona Spain"},{"name":"Unitat de Gen\u00e8tica, Departament de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64273-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.07.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.01.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.10.006"},{"key":"e_1_2_10_7_1","unstructured":"GonteroP BirtleA Comp\u00e9ratE DominguezJL LiedbergF MariappanP.Non\u2010muscle\u2010invasive Bladder Cancer (TaT1 and CIS) EAU Guidelines on 2024."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.03.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-210221"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.11.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acuro.2019.03.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.615091"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14921"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.144"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22152"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.06.018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22246"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14673"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.10.003"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.07.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.06.011"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04252-4"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:08:23Z","timestamp":1761743303000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/bju.16697"],"URL":"https:\/\/doi.org\/10.1111\/bju.16697","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}