{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:32:56Z","timestamp":1769203976824,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise\u2010induced urinary incontinence (UI) can hinder physical activity, particularly in women engaging in high\u2010impact activities. This condition is linked to reduced passive support of the urethra and bladder. Intravaginal devices that support pelvic structures may offer a solution, but high\u2010quality evidence is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>The study is an assessor\u2010blind randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and Secondary Endpoints<\/jats:title>\n                    <jats:p>Primary outcomes include frequency and amount of urine leakage during running over a 2\u2010week period, Patient Global Impression of Improvement, treatment satisfaction, and the International Consultation on Incontinence Questionnaire\u2010Urinary Incontinence Short Form, measured at baseline and after a 10\u2010week intervention. Secondary outcomes include adherence and unintended effects. A subset of participants will be invited to a laboratory\u2010based assessment at baseline and follow\u2010up involving pelvic floor morphometry and function to explore the mechanisms through which the interventions may be effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We aim to recruit 90 runners aged \u226518\u2009years, with female\u2010typical pelvic anatomy, who report running\u2010induced UI. After 2\u2009weeks of leakage tracking without any intervention, participants will be randomly assigned to a 10\u2010week pessary, tampon, or control intervention (1:1:1 ratio). Follow\u2010up assessments will be performed at 11\u201312 and 16\u2009weeks. Between\u2010 and within\u2010group differences will be evaluated with general linear models using an intent\u2010to\u2010treat approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration and Ethics<\/jats:title>\n                    <jats:p>\n                      This study is registered (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT 05773378), has been approved by the local Institutional Research Ethics Board, and follows the Declaration of Helsinki. Results will be published in peer\u2010reviewed journals, shared with clinicians and participants, and disseminated publicly.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16708","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:34:52Z","timestamp":1741761292000},"page":"931-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravaginal devices for running\u2010induced urinary incontinence symptoms in females: a study protocol"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-1833","authenticated-orcid":false,"given":"Sabine","family":"Vesting","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Ottawa  Ottawa Ontario 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