{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:11:09Z","timestamp":1788473469222,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015384","name":"Stichting Wetenschappelijk Onderzoek Prostaatkanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015384","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To present the long\u2010term outcomes of men with Grade Group (GG) 1 prostate cancer (PCa), included in the Prostate Cancer Research International Active Surveillance (PRIAS) study, and to assess the effect of the inclusion of magnetic resonance imaging (MRI) within the active surveillance (AS) protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The PRIAS study is a multicentre, prospective, web\u2010based cohort study monitoring patients on AS. In total, 8910 men with GG1 PCa were followed in 169 centres worldwide. The cumulative incidences of definitive treatment, metastasis and PCa\u2010specific mortality (PCSM) were estimated using competing risk analyses. Additionally, multivariable analysis was performed to assess the risk of reclassification, stratified by MRI performed around the time of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative incidence of definitive treatment 15\u2009years post\u2010diagnosis was 55% (95% confidence interval [CI] 53\u201357). For metastasis, the 15\u2010year cumulative incidence was 2.7% (95% CI 1.5\u20134.4). Eight men of died from PCa, resulting in a 15\u2010year cumulative PCSM incidence of 0.23% (95% CI 0.09\u20130.54). Compared to men with no MRI around the time of diagnosis, those who underwent MRI during the first 18\u2009months of AS were associated with a significantly higher risk of reclassification to \u2265GG2, while men with a positive MRI before diagnosis were associated with a higher risk of reclassification to GG2, but not to \u2265GG3. Men with GG2 PCa on MRI\u2010targeted rebiopsy who underwent definitive treatment did not show a statistically significant higher risk of 5\u2010year disease recurrence compared to those who had GG1 PCa on last biopsy during AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study confirms the safety of AS for GG1 PCa, with low metastasis and PCSM rates over 15\u2009years. Furthermore, the inclusion of MRI in AS prompts increased detection of GG2, leading to increased treatment rates despite similar short\u2010term risks. To minimise overtreatment, expanding eligibility for AS and the uptake of AS in men with favourable GG2 PCa is crucial to address the stage shift resulting from the increased accuracy of MRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16727","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T04:36:36Z","timestamp":1744605396000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term outcomes of active surveillance for Grade Group 1 prostate cancer and the impact of the use of MRI on overtreatment"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-7457","authenticated-orcid":false,"given":"Ivo I.","family":"de Vos","sequence":"first","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The 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H.","family":"Bangma","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-6448","authenticated-orcid":false,"given":"Sebastiaan","family":"Remmers","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-1708","authenticated-orcid":false,"given":"Monique J.","family":"Roobol","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Prostate Cancer Research International: Active Surveillance (PRIAS) 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