{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:23:01Z","timestamp":1788258181349,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the perioperative complications of the most common focal therapy (FT) modalities for prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We assessed the GeRmAn Nationwide inpatient Data (GRAND) from 2005 to 2023, provided by the Research Data Center of the Federal Bureau of Statistics. We compared perioperative outcomes of high\u2010intensity focused ultrasound (HIFU), hyperthermia, irreversible electroporation of the prostate, cryotherapy, vascular photodynamic therapy of the prostate (VTP), and transurethral ultrasound ablation, as well as HIFU vs non\u2010HIFU treatments in general. Furthermore, we evaluated the role of concomitant transurethral resection of the prostate (TURP) on perioperative complications. Finally, the complication rate of FT was also compared to brachytherapy and robot\u2010assisted radical prostatectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 10\u2009544 underwent FT. Most patients received HIFU (92%). The number of FT cases performed annually has been steadily decreasing. The most prevalent complication (9.6%) was urinary tract infection (HIFU: 10%, hyperthermia: 6.2%, cryotherapy: 6.8%, VTP: 3.9%). Haematuria was observed in 3.6% of all cases. In the multivariable regression, HIFU was associated with higher rates of urinary tract infections (10% vs 5.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) but lower rates of haematuria (3.4% vs 5.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and admission to the intensive care unit (0.7% vs 2.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to non\u2010HIFU procedures. Concomitant TURP was associated with higher transfusion (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), haematuria (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), sepsis (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), and urinary retention rates (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Most perioperative complications were statistically significantly worse in patients undergoing FT compared to brachytherapy, while most perioperative complications were better after FT vs robot\u2010assisted radical prostatectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the largest epidemiological comparative study on the risk of complications of the most common FT for prostate cancer, we were able to show an overall low risk of perioperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16746","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T06:33:51Z","timestamp":1745044431000},"page":"306-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Perioperative complications of focal therapy for prostate cancer: results from the GeRmAn Nationwide inpatient Data (\n                    <scp>GRAND)<\/scp>\n                    study"],"prefix":"10.1111","volume":"136","author":[{"given":"Nikolaos","family":"Pyrgidis","sequence":"first","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-6412","authenticated-orcid":false,"given":"Michael","family":"Chaloupka","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-7305","authenticated-orcid":false,"given":"Benedikt","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-9398","authenticated-orcid":false,"given":"Yannic","family":"Volz","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Weinhold","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Marcon","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennert","family":"Eismann","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Stief","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-0304","authenticated-orcid":false,"given":"Gerald B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-9291","authenticated-orcid":false,"given":"Maria","family":"Apfelbeck","sequence":"additional","affiliation":[{"name":"Department of Urology LMU Klinikum  Munich 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