{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:01:15Z","timestamp":1791910875213,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009094","name":"Turun Yliopistollisen Keskussairaalan Koulutus- ja Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007634","name":"Ida Montinin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005609","name":"Turun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of magnetic resonance imaging (MRI)\u2010guided transurethral ultrasound ablation (TULSA) as a minimally invasive alternative for benign prostatic obstruction (BPO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This prospective, single\u2010centre, early phase II study (NCT03350529) included 30 men with BPO scheduled for primary transurethral resection of the prostate. Assessments over 12\u2009months included uroflowmetry, prostate\u2010specific antigen (PSA) levels, and validated questionnaires at baseline and 3\u2010month intervals. MRI was performed at baseline and at 3 and 12\u2009months. Medication use and adverse events (AEs) were recorded and graded using the Clavien\u2013Dindo classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median patient age at treatment was 67\u2009years. During the 12\u2010month post\u2010TULSA follow\u2010up, prostate volume decreased from a median of 52 to 32\u2009mL, and PSA levels from 3.1 to 1.5\u2009\u03bcg\/L. The maximum flow rate increased from 11.1 to 18.3\u2009mL\/s (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the average flow rate from 4.2 to 9.1\u2009mL\/s (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Residual volume decreased from 71 to 40\u2009mL, and voided volume increased from 211 to 301\u2009mL. The International Prostate Symptom Score (IPSS) decreased from 17 to 4 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and IPSS quality of life score improved from 4 to 1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 26\u2010item Expanded Prostate Cancer Index Composite urinary irritative\/obstructive scores improved from 66 to 94 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and urinary incontinence scores improved from 86 to 100 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008). Sexual function remained stable or improved. A total of 13 AEs were recorded, including 11 Grade II events (urinary tract infections\/retentions) and one Grade IIIb event (epididymitis requiring drainage under general anaesthesia). All AEs resolved during follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transurethral ultrasound ablation appears to be a safe and effective experimental treatment for BPO, demonstrating clinically marked improvements in urinary function and quality of life at 12\u2009months while preserving continence and sexual functions. However, it is not yet recommended by guidelines, and long\u2010term outcomes and validation in larger cohorts remain essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16795","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:15:10Z","timestamp":1748402110000},"page":"473-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Magnetic resonance imaging<\/scp>\n                    \u2010guided transurethral ultrasound ablation for benign prostatic obstruction: 1\u2010year clinical outcomes of a phase II study"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-8662","authenticated-orcid":false,"given":"Antti","family":"Viitala","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9351-7177","authenticated-orcid":false,"given":"Mikael","family":"Anttinen","sequence":"additional","affiliation":[{"name":"Department of Urology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-0075","authenticated-orcid":false,"given":"Pietari","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"P\u00e4rssinen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Nurminen","sequence":"additional","affiliation":[{"name":"Department of Urology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-2601","authenticated-orcid":false,"given":"Teija","family":"Sainio","sequence":"additional","affiliation":[{"name":"Department of Medical Physics University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-1105","authenticated-orcid":false,"given":"Jani","family":"Saunavaara","sequence":"additional","affiliation":[{"name":"Department of Medical Physics University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-4604","authenticated-orcid":false,"given":"Pekka","family":"Taimen","sequence":"additional","affiliation":[{"name":"Laboratory Division, Department of Pathology Turku University Hospital  Turku Finland"},{"name":"Institute of Biomedicine and FICAN West Cancer Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-9639","authenticated-orcid":false,"given":"Roberto Blanco","family":"Sequeiros","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-0015","authenticated-orcid":false,"given":"Peter J.","family":"Bostr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Urology University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12745"},{"key":"e_1_2_11_3_1","unstructured":"GravasS CornuJN GacciMet\u00a0al.EAU guidelines: management of non\u2010neurogenic male LUTS. 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