{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:18:24Z","timestamp":1777954704715,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether long\u2010term magnetic resonance imaging (MRI) findings, alone or in combination with prostate\u2010specific antigen (PSA) density or the result of prior surveillance biopsies, could be used to omit biopsies occurring after patients have been on active surveillance (AS) for \u22655\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Analysis of a single\u2010institution AS cohort of patients with Grade Group (GG) 1 prostate cancer who underwent a scheduled 6\u2010year MRI and biopsy. Multivariable logistic regression was used to test the association between the Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score, PSA density, status of prior AS biopsy, and reclassification to GG \u22652. We then analysed how many GG \u22652 cancers would be missed if the 6\u2010year biopsy was avoided based on significant predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 49 of 221 men (22%) were reclassified to GG \u22652. PSA density and PI\u2010RADS scores 4\u20135 were significant predictors; a prior negative AS biopsy was inversely associated with GG \u22652. The risk of missing GG \u22652 if the 6\u2010year biopsy is omitted in men with an unsuspicious MRI (PI\u2010RADS 1\u20132) was 12% (95% confidence interval [CI] 5.3\u201319%). After testing combinations of MRI findings, PSA density, and the status of the prior biopsy, we found the lowest risk of GG \u22652 in patients with a prior negative biopsy and PSA density of &lt;0.10\u2009ng\/mL\/cc (5.3%, 95% CI 1.5\u201310%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An unsuspicious MRI at 6\u2009years is not enough alone to omit the 6\u2010year AS biopsy under current guidelines. Combining MRI findings, PSA density, and prior negative AS biopsies is a promising strategy to tailor surveillance intensity. Our findings should be replicated in larger cohorts prior to implementation in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16798","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:10:43Z","timestamp":1748491843000},"page":"500-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic resonance imaging for long\u2010term active surveillance biopsy decision\u2010making"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0779-0984","authenticated-orcid":false,"given":"Riccardo","family":"Leni","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Division of Experimental Oncology, Department of Urology IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele 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