{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:00Z","timestamp":1790660760511,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002690","name":"Ruth K. Broad Biomedical Research Foundation","doi-asserted-by":"publisher","award":["T32CA082088"],"award-info":[{"award-number":["T32CA082088"]}],"id":[{"id":"10.13039\/100002690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess health\u2010related quality of life (HRQoL) in women undergoing radical cystectomy (RC) for bladder cancer, focusing on identifying the pattern of recovery among women and any gender\u2010specific differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We analysed a prospective study of HRQoL in 411 participants undergoing RC (88 females), including 14 patient\u2010reported outcome measures over 2\u2009years of follow\u2010up. Generalised estimating equation models were used to estimate recovery in domain scores among women and analyse baseline HRQoL (among women based on diversion type and then comparing outcomes to males).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women who received a continent diversion (vs ileal conduit) had lower baseline Body Image (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037) and Social Functioning scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.046). In comparison to men, women had lower baseline Social Functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033), Body Image (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011), Sexual Functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), Emotional Functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and Mental Health (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Postoperatively, considerable improvements were seen in women for psychosocial health domains, but Emotional Functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and Mental Health (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024), for instance, remained meaningfully lower among women despite the improvements. Domains such as Physical Functioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.2) and Global QoL (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.12) were similar, although Pain (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.026) and Fatigue (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031) were worse in women postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women exhibit a similar, positive recovery trajectory in HRQoL after RC. However, both pre\u2010 and postoperatively, there are meaningfully lower psychosocial domain scores. Lower baseline Sexual Functioning scores and the differences observed in continent and ileal conduit diversion suggests tailored attention to this area in women. These findings have clinical implications for additional attention to psychosocial and emotional health during recovery after RC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16821","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:38:49Z","timestamp":1750387129000},"page":"728-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prospective health\u2010related quality of life in women undergoing radical cystectomy and urinary diversion"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1358-1441","authenticated-orcid":false,"given":"Matthew B.","family":"Clements","sequence":"first","affiliation":[{"name":"Institute of Urology, Department of Surgery Lahey Hospital and Medical Center  Burlington MA USA"},{"name":"UMass Chan Medical School  Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly R.","family":"Pekala","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Tin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Sjoberg","sequence":"additional","affiliation":[{"name":"Genetech Senior Principal Data Scientist  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Beech","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Herr","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Machele","family":"Donat","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-6503","authenticated-orcid":false,"given":"Andrew J.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Dalbagni","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard H.","family":"Bochner","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001071"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-43"},{"key":"e_1_2_9_4_1","first-page":"139","article-title":"Quality of life in patients with bladder cancer undergoing ileal conduit: A comparison of women versus men","volume":"32","author":"Siracusano S","year":"2018","journal-title":"In Vivo"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.10.061"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2006.359"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143042"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1680-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2020.1754906"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.09.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2021-053"},{"key":"e_1_2_9_13_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v015.i02"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.75"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.139"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269828"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00447-0"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00136-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.09.030"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000000528"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S368992"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13571"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2019.11.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.04.025"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.01.087"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:08:40Z","timestamp":1761743320000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/bju.16821"],"URL":"https:\/\/doi.org\/10.1111\/bju.16821","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"assertion":[{"value":"2025-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}