{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:55:31Z","timestamp":1777330531754,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the current European Association of Urology\/American Society of Clinical Oncology follow\u2010up (FU) schedule with routine use of ultrasonography (US)\u2009\u00b1\u2009US\u2010guided fine\u2010needle aspiration cytology (FNAC) in patients with lymph node (LN)\u2010negative penile squamous cell carcinoma (PSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We evaluated FU outcomes for low\u2010risk clinically LN\u2010negative (cN0) and intermediate\u2010 to high\u2010risk sentinel node (SN) negative (pathological N\u2010stage [pN]0) patients with PSCC at a high\u2010volume centre. We analysed routine inguinal US\u2009\u00b1\u2009FNAC (in case of a suspicious LN) during FU. A competing risk analysis was performed to calculate the cumulative risk of LN metastases in these groups, with local recurrence as competing risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 201 patients with PSCC were analysed, with 2694 inguinal US investigations being evaluated. FNAC was performed during 270 US procedures (10.0%). A LN metastasis was found in four of 270 US\u2009+\u2009FNAC procedures (1.5%, 0.2% of all US). All tumours were intermediate\u2010 to high\u2010risk tumours. Three occurred within the first year after primary treatment, and one at 20\u2009months. The cumulative risk of developing LN metastases in cN0 low\u2010risk tumours was 0% (no events occurred) and in SN\u2010negative intermediate\u2010 to high\u2010risk group 2.0%, both at 1\u2009year of FU. Two (out of four) patients with LN recurrence died from disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After adequate staging and treatment, patients with cN0\/pN0 PSCC rarely develop LN metastasis during FU. As these metastases generally occur within 1\u2009year after treatment, we recommend (3\u2010monthly) routine inguinal US only during the first year of FU. Thereafter, the frequency of FU visits and examinations can be reduced in patients capable of self\u2010examination of the penis, resulting in a substantial (up to a 50%) reduction of FU visits compared to current guideline recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16838","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:44:02Z","timestamp":1750725842000},"page":"675-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating follow\u2010up in patients with lymph node\u2010negative penile cancer at a high\u2010volume centre"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-4814","authenticated-orcid":false,"given":"Manon T.A.","family":"Vreeburg","sequence":"first","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam The 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Haan","sequence":"additional","affiliation":[{"name":"Department of Radiology The Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"van der Noort","sequence":"additional","affiliation":[{"name":"Department of Biometrics The Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik H.","family":"van Muilekom","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolien","family":"van Kesteren","sequence":"additional","affiliation":[{"name":"Department of Urology The Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek  Amsterdam The 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