{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:22:25Z","timestamp":1791516145594,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the oncological outcomes for patients with newly diagnosed bladder cancer, as long\u2010term oncological outcomes and natural history of different initial subtypes of diagnoses of bladder cancer are understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a prospective, multicentre population\u2010based cohort study, where newly diagnosed patients with bladder cancer from 1995 to 1996 in Stockholm County, Sweden were followed. The primary outcome was cancer\u2010specific mortality (CSM), separately analysed for low\u2010grade non\u2010muscle\u2010invasive bladder cancer (NMIBC Low), high\u2010grade non\u2010muscle\u2010invasive bladder cancer (NMIBC High), and muscle\u2010invasive bladder cancer (MIBC). We used cumulative incidence with competing risk to assess survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 526 patients were included, 396 had NMIBC. Out of 102 patients with T1, 37% died of bladder cancer during the 25\u2010year follow\u2010up. The rate of CSM for NMBIC Low was 3%, NMIBC High 26%, and MIBC 71%, respectively. For the operated patients with MIBC, the 5\u2010year CSM was 39%. Of the 178 patients with NMIBC High, 22% progressed to MIBC, 10% had lymph node progression, and 17% progressed to metastatic disease during the follow\u2010up. The main limitation of the study is that it was established 30\u2009years ago.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this population\u2010based study, we found that patients with NMIBC High had a persistent risk of CSM up to 25\u2009years from the initial diagnosis, more specifically in patients with T1 tumours. The study demonstrates the importance for optimal treatment for selective high\u2010risk T1 patients with long life expectancy, and high risk of progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16883","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T06:03:27Z","timestamp":1754633007000},"page":"95-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term oncological outcomes of bladder cancer: a\u00a0population\u2010based study with a 25\u2010year follow\u2010up"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0349-3290","authenticated-orcid":false,"given":"Linda","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Pelvic Cancer Karolinska University Hospital  Stockholm 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