{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:18:20Z","timestamp":1792293500233,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To quantify Nectin\u20104 expression in tumour lesions using the Nectin\u20104\u2010binding peptide Gallium\u201068\u2010N188 and positron emission tomography (PET)\/computed tomography (CT) in patients with advanced or metastasised urothelial cancer eligible for therapy with the Nectin\u20104\u2010directed antibody\u2013drug conjugate enfortumab vedotin, in combination with checkpoint inhibitor pembrolizumab (Ev\/P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 10 patients, Nectin\u20104 PET\/CT imaging was analysed before planned systemic therapy with Ev\/P based on standardised uptake value (SUV) measurements and the results were correlated to available microscopic findings on Nectin\u20104 immunohistochemistry and to clinical follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nectin\u20104 PET is suitable for detecting Nectin\u20104 expression in tumour lesions and demonstrates heterogeneity in Nectin\u20104 expression \u2013 for example, between lymph node metastases and organ metastases. PET imaging of Nectin\u20104 expression is therefore a potentially clinically relevant method for managing the application of Nectin\u20104\u2010targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We show, as a proof of principle, that Nectin\u20104 expression can be detected on imaging and serves as an innovative biomarker for targeted therapy in urothelial cancer. Intra\u2010individual heterogeneous expression of Nectin\u20104 in metastatic sites is frequent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16901","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T08:55:59Z","timestamp":1755939359000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Staging metastatic urothelial cancer with Nectin\u20104 imaging using Gallium\u201068\u2010\n                    <scp>N188 PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-5995","authenticated-orcid":false,"given":"Matthias","family":"Miederer","sequence":"first","affiliation":[{"name":"Department of Translational Imaging in Oncology, National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"Department of Nuclear Medicine, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pretze","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Abbate","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hartig","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-1313","authenticated-orcid":false,"given":"Joana","family":"do Mar Ferreira Machado","sequence":"additional","affiliation":[{"name":"Department of Translational Imaging in Oncology, National Center for Tumor Diseases (NCT), NCT\/UCC Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology, and Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Hober\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A.","family":"Bundschuh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kotzerke","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.08.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO-24-00470"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2014.32"},{"key":"e_1_2_8_5_1","first-page":"1163","article-title":"Upregulation of nectin\u20104 is associated with ITGB1 and vasculogenic mimicry and may serve as a predictor of poor prognosis in colorectal cancer","volume":"18","author":"Zhang J","year":"2019","journal-title":"Oncol 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