{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:49:26Z","timestamp":1787161766679,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess cure fraction and conditional survival probabilities for oncological outcomes in patients with T1 high\u2010grade (T1HG) non\u2010muscle\u2010invasive bladder carcinoma (NMIBC) treated with adequate Bacillus Calmette\u2010Gu\u00e9rin (BCG) immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This multi\u2010institutional retrospective cohort study included 1403 patients with T1HG NMIBC treated between 2007 and 2020, adhering to modern guidelines including mandatory second transurethral resection of bladder tumour and adequate BCG, defined as at least five of six induction doses and at least two of three maintenance doses. Cure fraction, defined as the proportion of patients who will never experience the event of interest, was calculated for recurrence\u2010free survival (RFS), progression\u2010free survival (PFS), cancer\u2010specific survival (CSS) and overall survival (OS) using a mixture cure model. Conditional survival probabilities over 5\u2009years were also computed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cure fractions were 41% (95% confidence interval [CI] 36%\u201346%) for RFS, 71% (95% CI 65%\u201376%) for PFS, 76% (95% CI 70%\u201383%) for CSS, and 38% (95% CI 28%\u201349%) for OS. Patients in very\u2010high\u2010risk subgroups, according to the European Association of Urology risk stratification, showed significantly lower cure fractions, particularly for PFS (61% [95% CI 50%\u201372%]) and CSS (59% [95% CI 34\u201384%]). Conditional survival analysis demonstrated that patient prognoses improved over time, with 5\u2010year conditional RFS, PFS, CSS and OS probabilities exceeding 90% for patients who were event\u2010free at 5\u2009years from diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that BCG immunotherapy achieves a statistical cure in select T1HG NMIBC patients, with avoidance of progression to muscle\u2010invasive bladder carcinoma in approximately 70% of cases. The probability of experiencing any adverse oncological event (recurrence, progression or death) is less than 10% among patients who remain event\u2010free for 5\u2009years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16913","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T02:55:41Z","timestamp":1756522541000},"page":"270-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Defining statistical cure in patients with T1 high\u2010grade non\u2010muscle\u2010invasive bladder carcinoma treated with BCG immunotherapy"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-8174","authenticated-orcid":false,"given":"Jos\u00e9 Daniel","family":"Subiela","sequence":"first","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"de la Parra","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Taborda","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-0344","authenticated-orcid":false,"given":"Alberto Artiles","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid 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Fern\u00e1ndez","family":"Mardomingo","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Del Olmo","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique L\u00f3pez","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, Universidad de Alcala  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-8845","authenticated-orcid":false,"given":"Daniel A.","family":"Gonz\u00e1lez\u2010Padilla","sequence":"additional","affiliation":[{"name":"Department of Urology Cl\u00ednica 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