{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:05:36Z","timestamp":1790190336969,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence of germline pathogenic variants (gPVs) in genes associated with female breast cancer in Dutch patients with metastatic prostate cancer (mPCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      In this prospective multicentre cohort study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915 centres), germline genetic testing of the genes\n                      <jats:italic>BRCA1<\/jats:italic>\n                      ,\n                      <jats:italic>BRCA2<\/jats:italic>\n                      ,\n                      <jats:italic>ATM<\/jats:italic>\n                      ,\n                      <jats:italic>CHEK2<\/jats:italic>\n                      and\n                      <jats:italic>PALB2<\/jats:italic>\n                      was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it to a reference population of 16\u2009823 individuals who underwent genetic testing for non\u2010oncological conditions. Additionally, we identified factors that increased the likelihood of carrying a gPV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 779 patients with mPCa underwent germline genetic testing, of whom 46 (5.9%) had a gPV in a DNA damage repair gene. Most gPVs were found in\n                      <jats:italic>CHEK2<\/jats:italic>\n                      (1100delC variant),\n                      <jats:italic>ATM<\/jats:italic>\n                      and\n                      <jats:italic>BRCA2<\/jats:italic>\n                      , all significantly more prevalent than in the reference population (odds ratios 2.4, 2.8 and 3.1, respectively). The prevalence of gPVs in\n                      <jats:italic>BRCA1<\/jats:italic>\n                      and\n                      <jats:italic>PALB2<\/jats:italic>\n                      was not significantly increased. Patients with a second primary cancer, a first\u2010 or second\u2010degree relative with breast cancer at age\u2009&lt;\u200950\u2009years, or pancreatic cancer, or Jewish ancestry had the highest likelihood of carrying a gPV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We found that gPVs in\n                      <jats:italic>CHEK2<\/jats:italic>\n                      ,\n                      <jats:italic>ATM<\/jats:italic>\n                      and\n                      <jats:italic>BRCA2<\/jats:italic>\n                      were associated with men presenting with mPCa. Several factors increased the likelihood of carrying such a variant and, in these cases, healthcare professionals should be aware of the need to offer germline genetic testing.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16916","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T12:48:28Z","timestamp":1756817308000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-8043","authenticated-orcid":false,"given":"Michiel","family":"Vlaming","sequence":"first","affiliation":[{"name":"Division Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Koole","sequence":"additional","affiliation":[{"name":"Division Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jeroen A.","family":"van Moorselaar","sequence":"additional","affiliation":[{"name":"Department of Urology Amsterdam UMC, Vrije Universiteit  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline M.A.","family":"Bleiker","sequence":"additional","affiliation":[{"name":"Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Clinical Genetics Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Clinical Genetics The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"van de Geer","sequence":"additional","affiliation":[{"name":"Division Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-1098","authenticated-orcid":false,"given":"Hanneke W.M.","family":"van Deutekom","sequence":"additional","affiliation":[{"name":"Division Laboratories, Pharmacy and Biomedical Genetics, Department of Genetics University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn J.L.","family":"Ligtenberg","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Pathology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaartje","family":"van Engelen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam University Medical Centers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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