{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:55:36Z","timestamp":1776102936429,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["179644"],"award-info":[{"award-number":["179644"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate sex differences in maximum storage detrusor pressure (Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage), focusing on Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage \u226540\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, an established risk factor for upper urinary tract damage, within the first year after spinal cord injury (SCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A cohort of patients with neurogenic lower urinary tract dysfunction due to acute traumatic or ischaemic SCI, managed according to the European Association of Urology Guidelines on Neuro\u2010Urology, prospectively underwent urodynamic investigations at 1, 3, 6 and 12\u2009months after SCI at a university SCI centre. Pearson's chi\u2010squared tests and multivariable regression analyses were used to compare outcomes between females and males.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 97 patients, 34% were female. Within the first year after SCI, 9% of females presented with a Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage \u226540\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, compared to 55% of males (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Females had lower Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage than males, with a grand mean (standard deviation [SD]) of 13\u2009(9) vs 30\u2009(20)\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O (coefficient\u2009=\u200918\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, 95% confidence interval [CI] 13\u201324\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Females also had lower detrusor overactivity leak\u2010point pressure (DOLPP) than males, with a grand mean (SD) of 15\u2009(4) vs 35\u2009(21)\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O (coefficient\u2009=\u200920\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O, 95% CI 11\u201329\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The cumulative incidence of antimuscarinic therapy and reported urinary incontinence was similar between sexes (female vs male: 55% vs 70%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.12; 53% vs 43%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.42, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Females rarely reached a Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage \u226540\u2009cmH\n                      <jats:sub>2<\/jats:sub>\n                      O during the first year after SCI and had lower Pdet\n                      <jats:sub>max<\/jats:sub>\n                      storage and DOLPP than males. However, the prevalence of urinary incontinence was similar between the sexes, suggesting the need for a more sex\u2010tailored approach to patient management.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16925","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:37:50Z","timestamp":1758260270000},"page":"1090-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Male sex is a risk factor for detrusor pressure jeopardising the upper urinary tract in patients with spinal cord injury"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-7266","authenticated-orcid":false,"given":"Veronika","family":"Birkh\u00e4user","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-6816","authenticated-orcid":false,"given":"Collene E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Swiss Paraplegic Research  Nottwil Switzerland"},{"name":"Faculty of Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-9331","authenticated-orcid":false,"given":"Marko","family":"Kozomara","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"},{"name":"Department of Urology Cantonal Hospital Lucerne  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-665X","authenticated-orcid":false,"given":"Martin W.G.","family":"Brinkhof","sequence":"additional","affiliation":[{"name":"Swiss Paraplegic Research  Nottwil Switzerland"},{"name":"Faculty of Health Sciences and Medicine University of Lucerne  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-5623","authenticated-orcid":false,"given":"Oliver","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-3494","authenticated-orcid":false,"given":"Lorenz","family":"Leitner","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology, Balgrist University Hospital 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