{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:19:43Z","timestamp":1791094783689,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the risk of urinary tract events after radical radiotherapy (RT) according to pre\u2010RT (IPSS) overall and within subgroups of prostate volume, type of RT, and use of neoadjuvant androgen\u2010deprivation therapy (ADT), as men who undergo RT for prostate cancer have a risk of urinary tract events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Men in the National Prostate Cancer Register of Sweden who underwent RT between 2018 and 2023 for whom IPSS was registered at diagnosis were included. The IPSS was stratified as: low, 0\u20137; moderate, 8\u201319; and severe, 20\u201335\u2009points. Urinary tract events were defined as lower urinary tract symptoms, infections, and urological procedures after treatment and assessed based on International Classification of Diseases and Related Health Problems, 10th Revision codes and procedures in The Patient Register. Competing risk of cumulative incidence proportion of urinary tract events at 3\u2009year after RT was computed according to the IPSS, prostate volume, type of RT, and use of neoadjuvant ADT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 4436 men included, 43% had mild, 44% moderate, and 13% severe pre\u2010RT IPSS. Incidence of urinary tract events after RT was 19% at 3\u2009years for men with mild IPSS, 28% for moderate IPSS, and 39% for severe IPSS. The association between IPSS and urinary tract events was observed within subgroups based on prostate volume, type of RT, and use of neoadjuvant ADT. A 5\u2010unit increase in IPSS carried a 20% increased risk of having a urinary tract event within 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A higher pre\u2010RT IPSS is an indicator of increased risk of urinary tract events after RT \u2013 both overall and within subgroups of prostate volume, type of RT, and use of neoadjuvant ADT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.16927","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:46:21Z","timestamp":1757677581000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary tract events after radical radiotherapy (RT) for prostate cancer according to pre\u2010RT International Prostate Symptom Score"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8050-9388","authenticated-orcid":false,"given":"Paolo","family":"Zaurito","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"},{"name":"Unit of Urology, Division of Oncology IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-6967","authenticated-orcid":false,"given":"Marcus","family":"Westerberg","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Gedeborg","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-1629","authenticated-orcid":false,"given":"Eugenio","family":"Ventimiglia","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Wilberg","family":"Orrason","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Thellenberg\u2010Karlsson","sequence":"additional","affiliation":[{"name":"Department Diagnostics and Intervention, Oncology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8873","authenticated-orcid":false,"given":"David","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Urology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2024.101670"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2022.03.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2020.09.022"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500855"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130404-200503000-00007"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36966-5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.03.040"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.10.042"},{"key":"e_1_2_12_10_1","first-page":"637","article-title":"International prostate symptom score (IPSS) change and changing factor in intensity\u2010modulated radiotherapy combined with androgen deprivation therapy for prostate cancer","volume":"77","author":"Tomita N","year":"2015","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.11.023"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13020233"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109544"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0019"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.12.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/sju.v59.42272"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/sju.v59.42656"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv305"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2016.1194460"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.05.022"},{"key":"e_1_2_12_21_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0366-z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.02.006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31131-6"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-22"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2012.09.010"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074311"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-014-0241-3"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.16927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:03:53Z","timestamp":1765357433000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.16927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/bju.16927"],"URL":"https:\/\/doi.org\/10.1111\/bju.16927","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}