{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:43:41Z","timestamp":1783745021665,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010148","name":"Asociaci\u00f3n Espa\u00f1ola de Urolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010148","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To conduct an external multicentre validation to evaluate Uromonitor\u00ae\u2010version 2 (v2; U\u2010monitor, Porto, Portugal) as a biomarker for detecting non\u2010muscle\u2010invasive bladder cancer (NMIBC) recurrence in an independent patient cohort in a real\u2010world\u2010evidence setting and compare it to cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The \u2018External Validation of Uromonitor as a Biomarker for Optimization of NMIBC Management by the Club Urol\u00f3gico Espa\u00f1ol de Tratamiento Oncol\u00f3gico Group\u2019 (EVALUATION\u2010CUETO) study is a prospective, multicentre, observational study (NCT05864599) conducted in Spain. Inclusion criteria included any risk group of patients with NMIBC undergoing follow\u2010up. The most recent (index) NMIBC tumours of any grade had to have been diagnosed within the past 3\u2009months to 2\u2009years. Regarding biomarkers, data from cystoscopy, cytology, and the Uromonitor\u2010v2 test were collected. Predictive performance parameters, including accuracy, area under the curve, negative and positive predictive values (NPV, PPV), sensitivity, and specificity, were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1178 patients with a mean age of 72\u2009years and a predominant male representation (80%) were included. Among the positive Uromonitor\u2010v2 cases, 64 (57.66%) exhibited a\n                      <jats:italic>TERT<\/jats:italic>\n                      promoter mutation, and 59 (53.15%) harboured a\n                      <jats:italic>FGFR3<\/jats:italic>\n                      mutation. No\n                      <jats:italic>KRAS<\/jats:italic>\n                      mutations were found. For the total population, Uromonitor\u2010v2 demonstrated high specificity (0.93) and NPV (0.93), but low sensitivity (0.36) and PPV (0.36), indicating a limited ability to detect all recurrences and confirm positive cases. Performance varied across tumour grades, with low\u2010grade tumours showing a low sensitivity of 0.32 and high\u2010grade tumours achieving a higher but insufficient sensitivity of 0.44. Specificity remained consistent at 0.93 across all groups. Uromonitor\u2010v2 achieved higher accuracy compared to cytology alone, with the combined approach further improving overall predictive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The strong specificity and NPV observed across all studies suggest a role of Uromonitor\u2010v2 as a potential tool for NMIBC follow\u2010up, particularly in ruling out recurrence and clarifying doubtful cystoscopy results. However, the unexpectedly low sensitivity reported in this external multicentre validation suggests the need for further investigation before routine clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70010","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:49:47Z","timestamp":1759315787000},"page":"216-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["External validation of the Uromonitor\u00ae\u2010version 2 urine test as a biomarker for optimisation of non\u2010muscle\u2010invasive bladder cancer management"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-4641","authenticated-orcid":false,"given":"Jos\u00e9","family":"Rubio\u2010Briones","sequence":"first","affiliation":[{"name":"Urology Hospital VITHAS 9 de Octubre  Valencia 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