{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:45:07Z","timestamp":1791380707552,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic performance of perilesional biopsies (PLBx) compared to other biopsy strategies, assessing the impact of the Prostate Imaging\u2010Reporting and Data System (PI\u2010RADS) score and biopsy history in patients with a visible lesion at multiparametric magnetic resonance imaging of the prostate (mpMRI), as the European Association of Urology guidelines recommend combining MRI\u2010targeted biopsies (TBx) with PLBx as an alternative to systematic biopsies (SBx) even though evidence is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We relied on a cohort of 2852 patients with PI\u2010RADS \u22653 lesions undergoing TBx\u2009+\u2009SBx at three tertiary referral centres. The primary outcome was detection of clinically significant PCa (csPCa) (International Society of Urological Pathology Grade Group [ISUP GG] \u22652) of TBx\u2009+\u2009PLBx vs TBx\u2009+\u2009SBx. Results were stratified by PI\u2010RADS score and biopsy history. The PLBx cores were defined as samples taken from prostate sectors adjacent to the mpMRI lesion. We finally assessed insignificant PCa (insPCa, i.e., ISUP GG 1) detection across biopsy strategies. Differences were assessed using the chi\u2010square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Detection of csPCa was 48%. Overall, TBx\u2009+\u2009SBx had a higher csPCa detection rate than TBx\u2009+\u2009PLBx (50% vs 45%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03), particularly in PI\u2010RADS 3 lesions (26% vs 21%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and active surveillance (AS) patients (46% vs 40%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04). No significant differences were found in PI\u2010RADS 4 (53% vs 50%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.1) or PI\u2010RADS 5 (76% vs 75%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.1). In the biopsy na\u00efve and previous negative biopsy groups, csPCa detection was similar between strategies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, TBx\u2009+\u2009SBx offers the highest detection of csPCa. Even though TBx\u2009+\u2009PLBx may be considered in PI\u2010RADS 4\u20135 lesions to reduce insPCa detection, TBx\u2009+\u2009SBx remains the preferred strategy for PI\u2010RADS 3 and AS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70027","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T07:05:53Z","timestamp":1760339153000},"page":"282-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Utility of\n                    <scp>MRI<\/scp>\n                    perilesional biopsy in prostate cancer: impact of the Prostate Imaging\u2010Reporting and Data System and biopsy history"],"prefix":"10.1111","volume":"137","author":[{"given":"Donato","family":"Cannoletta","sequence":"first","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-0069","authenticated-orcid":false,"given":"Armando","family":"Stabile","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9523-3400","authenticated-orcid":false,"given":"Leonardo","family":"Quarta","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barletta","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7828-6876","authenticated-orcid":false,"given":"Francesco","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-1868","authenticated-orcid":false,"given":"Simone","family":"Scuderi","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Porzi","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan 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Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-1800","authenticated-orcid":false,"given":"Elio","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological Research Institute IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Brembilla","sequence":"additional","affiliation":[{"name":"Department of Radiology IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Cobelli","sequence":"additional","affiliation":[{"name":"Department of Radiology IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandaglia","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Unit of Urology, Urological 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