{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:23:23Z","timestamp":1790101403103,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the oncological control and functional outcomes of focal laser ablation (FLA) in the management of localised prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted according to the Preferred Reporting Items for Systematic Review and Meta\u2010Analyses guidelines. An electronic search identified studies reporting outcomes of FLA for localised prostate cancer. The primary outcome was oncological control, assessed by recurrence on follow\u2010up biopsy and prostate\u2010specific antigen (PSA) level reduction. Secondary outcomes included adverse events and functional outcomes, specifically sexual and urinary function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search identified 12 studies for inclusion, including 421 patients who underwent FLA for localised prostate cancer. The rate of recurrence of clinically significant cancer on biopsy following FLA was 15% (95% confidence interval [CI] 11\u201320%). The mean reduction in PSA level at 12\u2010months post\u2010FLA was 2.3\u2009ng\/mL (95% CI 1.5\u20133.2\u2009ng\/mL). There was a statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not clinically significant (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20090.29) decrease in sexual function, and no statistically significant change in urinary function following FLA. Heterogeneity in patient selection, follow\u2010up protocols, and definitions of recurrence limit cross\u2010study comparisons and generalisability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present systematic review and meta\u2010analysis found that FLA provides oncological control comparable to other focal therapies while preserving functional outcomes. However, the limited availability of high\u2010quality comparative studies highlights the need for further robust studies to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.70064","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:55:07Z","timestamp":1762307707000},"page":"251-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Focal laser ablation in prostate cancer: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"137","author":[{"given":"Ymer","family":"Bushati","sequence":"first","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9865-5738","authenticated-orcid":false,"given":"Allen Ao","family":"Guo","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Muston","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidin","family":"Bushati","sequence":"additional","affiliation":[{"name":"University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-014X","authenticated-orcid":false,"given":"Niranjan","family":"Sathianathen","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Parkville New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kam","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Urology Nepean Hospital  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Teoh","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong  Ma Liu Shui Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Khadra","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Urology Nepean Hospital  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-6114","authenticated-orcid":false,"given":"Isaac","family":"Thangasamy","sequence":"additional","affiliation":[{"name":"Nepean Urology Research Group  Kingswood New South Wales Australia"},{"name":"University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Urology Nepean Hospital  Kingswood New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13049"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-7-10"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/589160"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002757"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-024-04482-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2024.102101"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/iju.iju_370_23"},{"key":"e_1_2_9_11_1","first-page":"1","article-title":"Established focal therapy\u2014HIFU, IRE, or cryotherapy\u2014where are we now?\u2014a systematic review and meta\u2010analysis","volume":"28","author":"Tay KJ","year":"2024","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_9_13_1","unstructured":"MogaC GuoB SchopflocherD HarstallC.Development of a quality appraisal tool for case series studies using a modified delphi technique.2012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210414"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.15526"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.03.011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.07.074"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16152620"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.029"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.06.035"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071404"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5152\/dir.2021.20095"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2022.4.406"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.04.017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2018.09.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2014.965687"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-024-04840-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01847-y"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06148.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.1527"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-019-02036-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.03.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.02.047"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000044"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.015"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.2230"},{"key":"e_1_2_9_40_1","first-page":"11128","article-title":"Early functional outcomes following partial gland cryo\u2010ablation","volume":"29","author":"Thakker S","year":"2022","journal-title":"Can J Urol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.08.008"},{"key":"e_1_2_9_42_1","article-title":"PD17\u201001 outpatient trans\u2010rectal MR\u2010guided laser focal therapy phase ii clinical trial: ten\u2010year interim results","volume":"203","author":"Feller J","year":"2020","journal-title":"J Urol"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2214122"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2017.8"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bju.70064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.70064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:14:58Z","timestamp":1785964498000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.70064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bju.70064"],"URL":"https:\/\/doi.org\/10.1111\/bju.70064","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}